SERPINB13 and PRTN3

Data Source:
HPRD (in vitro)

		SERPINB13	PRTN3
Description		serpin family B member 13	proteinase 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Speck Lysosomal Lumen Extracellular Exosome	Extracellular Region Extracellular Space Cytosol Plasma Membrane Azurophil Granule Lumen Intracellular Membrane-bounded Organelle Plasma Membrane Raft Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Protease Binding Serine-type Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding	Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Serine-type Peptidase Activity Enzyme Binding
	Biological Process	Response To UV Negative Regulation Of Endopeptidase Activity Regulation Of Proteolysis Regulation Of Keratinocyte Differentiation Negative Regulation Of Keratinocyte Apoptotic Process	Proteolysis Membrane Protein Ectodomain Proteolysis Phagocytosis Blood Coagulation Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Antimicrobial Humoral Response Collagen Catabolic Process Neutrophil Degranulation Positive Regulation Of GTPase Activity Cell-cell Junction Maintenance Negative Regulation Of Phagocytosis Neutrophil Extravasation Mature Conventional Dendritic Cell Differentiation
Pathways		RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	Common Pathway of Fibrin Clot Formation Other interleukin signaling Neutrophil degranulation Antimicrobial peptides
Drugs			Elafin
Diseases
GWAS		Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252)	Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Blood protein levels ( 30072576 29875488) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Monocyte percentage of white cells ( 32888494 27863252) White blood cell count (basophil) ( 27863252)
Interacting Genes		9 interacting genes: CTSB CTSG CTSK CTSL DLG2 ELANE PLG PRSS1 PRTN3	13 interacting genes: CAMP ELN F2R F2RL1 IL1B IL32 ITGB2 RELA SERPINA1 SERPINB1 SERPINB13 SMAD3 TNF
Entrez ID		5275	5657
HPRD ID		05118	01512
Ensembl ID		ENSG00000197641	ENSG00000196415
Uniprot IDs		A0A0A0MQW3 B7Z447 Q9UIV8	P24158
PDB IDs			1FUJ
Enriched GO Terms of Interacting Partners?
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