SERPINB13 and CTSG

Data Source:
HPRD (in vitro)

		SERPINB13	CTSG
Description		serpin family B member 13	cathepsin G
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Speck Lysosomal Lumen Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Cytoplasm Plasma Membrane Cell Surface Cytoplasmic Stress Granule Secretory Granule Azurophil Granule Lumen Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Protease Binding Serine-type Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding	Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity
	Biological Process	Response To UV Negative Regulation Of Endopeptidase Activity Regulation Of Proteolysis Regulation Of Keratinocyte Differentiation Negative Regulation Of Keratinocyte Apoptotic Process	Angiotensin Maturation Protein Phosphorylation Proteolysis Immune Response Antimicrobial Humoral Response Antibacterial Humoral Response Extracellular Matrix Disassembly Neutrophil Degranulation Cellular Protein Metabolic Process Positive Regulation Of Immune Response Defense Response To Gram-negative Bacterium Defense Response To Fungus Neutrophil-mediated Killing Of Gram-positive Bacterium Cellular Response To Lipopolysaccharide
Pathways		RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Metabolism of Angiotensinogen to Angiotensins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-1 processing Neutrophil degranulation Antimicrobial peptides Suppression of apoptosis Purinergic signaling in leishmaniasis infection
Drugs			Bis-Napthyl Beta-Ketophosphonic Acid 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid
Diseases
GWAS		Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252)	Congenital heart disease (maternal effect) ( 28468790) Conotruncal heart defects (maternal effects) ( 28468790)
Interacting Genes		9 interacting genes: CTSB CTSG CTSK CTSL DLG2 ELANE PLG PRSS1 PRTN3	30 interacting genes: AGT C3 CAMP CASP7 CXCL12 CXCR4 CYSRT1 ERBIN F2R F2RL1 F2RL2 F5 GP1BA IGFBP3 KNG1 KRT31 LRP1 NOTCH2NLA PARP1 PICK1 PPBP SDC1 SELPLG SERPINA1 SERPINA3 SERPINB13 SERPINB4 SERPIND1 THBS1 VCAM1
Entrez ID		5275	1511
HPRD ID		05118	00289
Ensembl ID		ENSG00000197641	ENSG00000100448
Uniprot IDs		A0A0A0MQW3 B7Z447 Q9UIV8	P08311
PDB IDs			1AU8 1CGH 1KYN 1T32 6VTM
Enriched GO Terms of Interacting Partners?
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