SERPINB13 and CTSB

Data Source:
HPRD (in vitro)

		SERPINB13	CTSB
Description		serpin family B member 13	cathepsin B
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Speck Lysosomal Lumen Extracellular Exosome	Extracellular Region Extracellular Space Intracellular Anatomical Structure Lysosome Apical Plasma Membrane Endolysosome Lumen Melanosome Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Protease Binding Serine-type Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding	Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Peptidase Activity Cysteine-type Peptidase Activity Proteoglycan Binding
	Biological Process	Response To UV Negative Regulation Of Endopeptidase Activity Regulation Of Proteolysis Regulation Of Keratinocyte Differentiation Negative Regulation Of Keratinocyte Apoptotic Process	Toll-like Receptor Signaling Pathway Proteolysis Collagen Catabolic Process Epithelial Cell Differentiation Regulation Of Apoptotic Process Neutrophil Degranulation Regulation Of Catalytic Activity Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Thyroid Hormone Stimulus
Pathways		RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	Collagen degradation Trafficking and processing of endosomal TLR Assembly of collagen fibrils and other multimeric structures MHC class II antigen presentation Neutrophil degranulation
Drugs			2-Aminoethanimidic Acid 3-Amino-4-Oxybenzyl-2-Butanone 3-Methylphenylalanine N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline 2-Pyridinethiol Diphenylacetic acid N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-Butane N-{[(2S,3S)-3-(Ethoxycarbonyl)-2-oxiranyl]carbonyl}-L-threonyl-L-isoleucine N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCINE BENZYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE METHYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ALANINE N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ISOLEUCINE N-({(2S,3S)-3-[(BENZYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINE
Diseases			Tropical calcific pancreatitis
GWAS		Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Blood protein levels ( 29875488 28240269) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Dental caries (decayed, missing and filled teeth) ( 31533690) Fish- and plant-related diet ( 32066663) General risk tolerance (MTAG) ( 30643258) Leprosy ( 27976721) Parkinson's disease ( 32201043 28892059) Parkinson's disease in GBA mutation carriers ( 31755958) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Processed meat consumption ( 32066663) Refractive error ( 32231278) Triglyceride levels ( 29083408) Triglycerides ( 30275531)
Interacting Genes		9 interacting genes: CTSB CTSG CTSK CTSL DLG2 ELANE PLG PRSS1 PRTN3	37 interacting genes: A2M ACAN ADAMTSL4 ANXA2 ANXA7 APOE APP BAG6 BGLAP CDKN1A CST3 CST7 CSTA CSTB CTSD ERCC6 FAM118B HNRNPD HSPB2 IGF1 INS MARCKS MTDH PARP1 PLAU REN RGS2 S100A10 SERPINB13 SLPI SPHK1 SPINT2 SPRY2 SRPX2 STK11 UBQLN4 XRN1
Entrez ID		5275	1508
HPRD ID		05118	00287
Ensembl ID		ENSG00000197641	ENSG00000164733
Uniprot IDs		A0A0A0MQW3 B7Z447 Q9UIV8	A0A024R374 B4DMY4 P07858 Q5HYG5
PDB IDs			1CSB 1GMY 1HUC 1PBH 2IPP 2PBH 3AI8 3CBJ 3CBK 3K9M 3PBH 5MBL 5MBM 6AY2
Enriched GO Terms of Interacting Partners?
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