PFKFB2 and GCK

Data Source:
HPRD (two hybrid)

		PFKFB2	GCK
Description		6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	glucokinase
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GO Annotations	Cellular Component	Nucleoplasm Cytosol	Nucleoplasm Mitochondrion Cytosol
	Molecular Function	6-phosphofructo-2-kinase Activity Fructose-2,6-bisphosphate 2-phosphatase Activity Protein Binding ATP Binding Protein Kinase Binding	Glucokinase Activity Protein Binding ATP Binding Glucose Binding Fructokinase Activity Mannokinase Activity
	Biological Process	Fructose Metabolic Process Fructose 2,6-bisphosphate Metabolic Process Glucose Catabolic Process Lactate Metabolic Process Glycolytic Process Response To Glucose Dephosphorylation Positive Regulation Of Insulin Secretion Positive Regulation Of Glucokinase Activity Positive Regulation Of Glycolytic Process Carbohydrate Phosphorylation	Cellular Glucose Homeostasis Glycolytic Process Regulation Of Glycolytic Process Positive Regulation Of Insulin Secretion Cellular Response To Insulin Stimulus Glucose Homeostasis Cellular Response To Leptin Stimulus Negative Regulation Of Gluconeogenesis Positive Regulation Of Glycogen Biosynthetic Process Carbohydrate Phosphorylation Regulation Of Insulin Secretion Glucose 6-phosphate Metabolic Process Detection Of Glucose Canonical Glycolysis
Pathways		Regulation of glycolysis by fructose 2,6-bisphosphate metabolism	Regulation of Glucokinase by Glucokinase Regulatory Protein Regulation of gene expression in beta cells Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) Glycolysis FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs			Beta-D-Glucose 2-amino-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide 3-[(4-fluorophenyl)sulfanyl]-N-(4-methyl-1,3-thiazol-2-yl)-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridine-2-carboxamide 2-(methylamino)-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide 2-AMINO-4-FLUORO-5-[(1-METHYL-1H-IMIDAZOL-2-YL)SULFANYL]-N-(1,3-THIAZOL-2-YL)BENZAMIDE
Diseases			Maturity onset diabetes of the young (MODY) Permanent neonatal diabetes mellitus (PNDM)
GWAS		Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31152163) White blood cell count ( 32888494)	Birth weight ( 31043758 27680694) Blood glucose levels ( 31928498) Blood sugar levels ( 29403010) Coronary artery disease and triglyceride levels (multivariate analysis) ( 30525989) Fasting blood glucose ( 25631608 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting plasma glucose ( 25187374 19060907) Glycated hemoglobin levels ( 24647736 20858683 24244560 31213470 19096518 28898252) Glycemic traits ( 23575436) Glycemic traits (pleiotropy) ( 31021400) Hematological and biochemical traits ( 31902109) Hemoglobin A1c levels ( 29403010) HOMA-B (corrected for HOMA-IR) ( 30369944) Homeostasis model assessment of beta-cell function ( 20081858) Metabolic syndrome ( 22399527) Metabolite levels ( 21909109 23823483) Metabolite levels (small molecules and protein measures) ( 27005778) Offspring birth weight ( 31043758 29309628) Pulse pressure ( 27841878 30578418) Triglyceride levels ( 32203549 32154731 31928498) Triglycerides ( 30275531) Type 2 diabetes ( 22885922 30297969 32499647 30718926)
Interacting Genes		9 interacting genes: AKT1 GCK PRKAA1 PRKAA2 PRKACA PRKCA YWHAG YWHAQ YWHAZ	6 interacting genes: GCKR INS PCNA PFKFB2 PFKFB3 SPDYE4
Entrez ID		5208	2645
HPRD ID		01383	00680
Ensembl ID		ENSG00000123836	ENSG00000106633
Uniprot IDs		O60825	P35557 Q53Y25
PDB IDs		5HTK	1GLK 1V4S 1V4T 3A0I 3F9M 3FGU 3FR0 3GOI 3H1V 3ID8 3IDH 3IMX 3QIC 3S41 3VEV 3VEY 3VF6 4DCH 4DHY 4ISE 4ISF 4ISG 4IWV 4IXC 4L3Q 4LC9 4MLE 4MLH 4NO7 4RCH 5V4W 5V4X 6E0E 6E0I
Enriched GO Terms of Interacting Partners?
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