GCK and PFKFB3

Data Source:
BioGRID (protein complementation assay)

		GCK	PFKFB3
Description		glucokinase	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Cytosol	Nucleoplasm Cytosol
	Molecular Function	Glucokinase Activity Protein Binding ATP Binding Glucose Binding Fructokinase Activity Mannokinase Activity	6-phosphofructo-2-kinase Activity Fructose-2,6-bisphosphate 2-phosphatase Activity Protein Binding ATP Binding
	Biological Process	Cellular Glucose Homeostasis Glycolytic Process Regulation Of Glycolytic Process Positive Regulation Of Insulin Secretion Cellular Response To Insulin Stimulus Glucose Homeostasis Cellular Response To Leptin Stimulus Negative Regulation Of Gluconeogenesis Positive Regulation Of Glycogen Biosynthetic Process Carbohydrate Phosphorylation Regulation Of Insulin Secretion Glucose 6-phosphate Metabolic Process Detection Of Glucose Canonical Glycolysis	Fructose Metabolic Process Fructose 2,6-bisphosphate Metabolic Process Dephosphorylation Positive Regulation Of Glycolytic Process Carbohydrate Phosphorylation
Pathways		Regulation of Glucokinase by Glucokinase Regulatory Protein Regulation of gene expression in beta cells Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) Glycolysis FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
Drugs		Beta-D-Glucose 2-amino-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide 3-[(4-fluorophenyl)sulfanyl]-N-(4-methyl-1,3-thiazol-2-yl)-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridine-2-carboxamide 2-(methylamino)-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide 2-AMINO-4-FLUORO-5-[(1-METHYL-1H-IMIDAZOL-2-YL)SULFANYL]-N-(1,3-THIAZOL-2-YL)BENZAMIDE
Diseases		Maturity onset diabetes of the young (MODY) Permanent neonatal diabetes mellitus (PNDM)
GWAS		Birth weight ( 31043758 27680694) Blood glucose levels ( 31928498) Blood sugar levels ( 29403010) Coronary artery disease and triglyceride levels (multivariate analysis) ( 30525989) Fasting blood glucose ( 25631608 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting plasma glucose ( 25187374 19060907) Glycated hemoglobin levels ( 24647736 20858683 24244560 31213470 19096518 28898252) Glycemic traits ( 23575436) Glycemic traits (pleiotropy) ( 31021400) Hematological and biochemical traits ( 31902109) Hemoglobin A1c levels ( 29403010) HOMA-B (corrected for HOMA-IR) ( 30369944) Homeostasis model assessment of beta-cell function ( 20081858) Metabolic syndrome ( 22399527) Metabolite levels ( 21909109 23823483) Metabolite levels (small molecules and protein measures) ( 27005778) Offspring birth weight ( 31043758 29309628) Pulse pressure ( 27841878 30578418) Triglyceride levels ( 32203549 32154731 31928498) Triglycerides ( 30275531) Type 2 diabetes ( 22885922 30297969 32499647 30718926)	Alopecia areata ( 25608926) Asthma ( 31959851 31619474) Asthma (childhood onset) ( 31036433) Celiac disease ( 22057235 24999842) Crohn's disease ( 28067908) Latent autoimmune diabetes ( 30254083) Metabolite levels ( 23823483) Obesity (extreme) ( 31888951) Plasma anti-thyroid peroxidase levels ( 29678681) Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) ( 25117820) Selective IgA deficiency ( 27723758) Western dietary pattern ( 28644415)
Interacting Genes		6 interacting genes: GCKR INS PCNA PFKFB2 PFKFB3 SPDYE4	2 interacting genes: GCK PFKFB1
Entrez ID		2645	5209
HPRD ID		00680	05612
Ensembl ID		ENSG00000106633	ENSG00000170525
Uniprot IDs		P35557 Q53Y25	B7Z8A0 Q16875
PDB IDs		1GLK 1V4S 1V4T 3A0I 3F9M 3FGU 3FR0 3GOI 3H1V 3ID8 3IDH 3IMX 3QIC 3S41 3VEV 3VEY 3VF6 4DCH 4DHY 4ISE 4ISF 4ISG 4IWV 4IXC 4L3Q 4LC9 4MLE 4MLH 4NO7 4RCH 5V4W 5V4X 6E0E 6E0I	2AXN 2DWO 2DWP 2I1V 3QPU 3QPV 3QPW 4D4J 4D4K 4D4L 4D4M 4MA4 5AJV 5AJW 5AJX 5AJY 5AJZ 5AK0 6ETJ 6HVH 6HVI 6HVJ 6IBX 6IBY 6IBZ 6IC0
Enriched GO Terms of Interacting Partners?
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