GCK and GCKR

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		GCK	GCKR
Description		glucokinase	glucokinase regulator
Image
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Cytosol	Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Glucokinase Activity Protein Binding ATP Binding Glucose Binding Fructokinase Activity Mannokinase Activity	Enzyme Inhibitor Activity Protein Binding Enzyme Binding Carbohydrate Binding Fructose-6-phosphate Binding
	Biological Process	Cellular Glucose Homeostasis Glycolytic Process Regulation Of Glycolytic Process Positive Regulation Of Insulin Secretion Cellular Response To Insulin Stimulus Glucose Homeostasis Cellular Response To Leptin Stimulus Negative Regulation Of Gluconeogenesis Positive Regulation Of Glycogen Biosynthetic Process Carbohydrate Phosphorylation Regulation Of Insulin Secretion Glucose 6-phosphate Metabolic Process Detection Of Glucose Canonical Glycolysis	Carbohydrate Metabolic Process Regulation Of Glycolytic Process Protein Import Into Nucleus Response To Fructose Negative Regulation Of Glucokinase Activity Glucose Homeostasis Urate Metabolic Process Triglyceride Homeostasis Carbohydrate Derivative Metabolic Process
Pathways		Regulation of Glucokinase by Glucokinase Regulatory Protein Regulation of gene expression in beta cells Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) Glycolysis FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	Regulation of Glucokinase by Glucokinase Regulatory Protein Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
Drugs		Beta-D-Glucose 2-amino-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide 3-[(4-fluorophenyl)sulfanyl]-N-(4-methyl-1,3-thiazol-2-yl)-6-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]pyridine-2-carboxamide 2-(methylamino)-N-(4-methyl-1,3-thiazol-2-yl)-5-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]benzamide 2-AMINO-4-FLUORO-5-[(1-METHYL-1H-IMIDAZOL-2-YL)SULFANYL]-N-(1,3-THIAZOL-2-YL)BENZAMIDE
Diseases		Maturity onset diabetes of the young (MODY) Permanent neonatal diabetes mellitus (PNDM)
GWAS		Birth weight ( 31043758 27680694) Blood glucose levels ( 31928498) Blood sugar levels ( 29403010) Coronary artery disease and triglyceride levels (multivariate analysis) ( 30525989) Fasting blood glucose ( 25631608 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting plasma glucose ( 25187374 19060907) Glycated hemoglobin levels ( 24647736 20858683 24244560 31213470 19096518 28898252) Glycemic traits ( 23575436) Glycemic traits (pleiotropy) ( 31021400) Hematological and biochemical traits ( 31902109) Hemoglobin A1c levels ( 29403010) HOMA-B (corrected for HOMA-IR) ( 30369944) Homeostasis model assessment of beta-cell function ( 20081858) Metabolic syndrome ( 22399527) Metabolite levels ( 21909109 23823483) Metabolite levels (small molecules and protein measures) ( 27005778) Offspring birth weight ( 31043758 29309628) Pulse pressure ( 27841878 30578418) Triglyceride levels ( 32203549 32154731 31928498) Triglycerides ( 30275531) Type 2 diabetes ( 22885922 30297969 32499647 30718926)	Albumin-globulin ratio ( 29403010) Alcohol consumption ( 27911795 28937693 31358974) Alcohol consumption (drinkers vs non-drinkers) ( 31959922) Alcohol consumption (drinks per week) ( 28485404 30643258 30679032) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alcohol consumption in current drinkers ( 28937693) Alcohol use disorder ( 30940813) Alcohol use disorder (consumption score) ( 30940813 30336701) Alcohol use disorder (total score) ( 30336701) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 29403010) Bitter alcoholic beverage consumption ( 31046077) Bitter beverage consumption ( 31046077) Blood glucose levels ( 29615537) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Blood protein levels in cardiovascular risk ( 28369058) Blood sugar levels ( 29403010) Branched-chain amino acid levels (Isoleucine) ( 27898682) Branched-chain amino acid levels (Leucine) ( 27898682) Branched-chain amino acid levels (Valine) ( 27898682) Breast size ( 22747683) C-reactive protein ( 18439548) C-reactive protein levels ( 29403010 30388399 21300955) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Calcium levels ( 24068962 20705733) Cardiovascular disease risk factors ( 21943158) Chloride levels ( 29403010) Cholesterol ( 31902109) Cholesterol, total ( 24097068 25961943 20686565 26582766) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic kidney disease ( 29124443 20383146) circulating leptin levels ( 32917775 26833098) circulating leptin levels adjusted for BMI ( 32917775 26833098) Circulating leptin levels or fasting insulin levels ( 32341051) Circulating leptin levels or HOMA-IR ( 32341051) Circulating leptin levels or type 2 diabetes ( 32341051) Coffee consumption ( 31959922 31046077) Coffee consumption (cups per day) ( 31837886 25288136) Creatine kinase levels ( 29403010) Creatinine levels ( 29403010) Crohn's disease ( 28067908 21102463) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) Factor VII activity ( 30642921) Factor VII activity or levels ( 30642921) Fasting blood glucose ( 25631608 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood glucose adjusted for BMI ( 25625282) Fasting blood insulin ( 25631608 20081858 22581228) Fasting blood insulin (BMI interaction) ( 22581228) Fasting blood insulin adjusted for BMI ( 25625282) Fasting plasma glucose ( 25187374 28270201 22508271) Fasting triglyceride levels ( 32603185) Gallstone disease ( 30504769 27094239) Gamma glutamyl transferase levels ( 29403010) Gestational insulin sensitivity ( 32556615) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Glucose homeostasis traits ( 25524916) Glycemic traits (pleiotropy) ( 31021400) Glycemic traits (pregnancy) ( 23903356) Gondoic acid (20:1n-9) levels ( 28298293) Gout ( 25646370 32238385 31578528 27899376) Gout (combined type) ( 32238385) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Height ( 25282103 31562340) Hematocrit ( 32888494 27863252) Hematological and biochemical traits ( 20139978) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Homeostasis model assessment of insulin resistance ( 20081858) Hypertriglyceridemia ( 31910446 27599772 23505323 20657596) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 28067908) Kidney stones ( 31729369) L-selectin levels ( 25576479) Lactate dehydrogenase levels ( 29403010) LDL cholesterol ( 18179892 30275531) LDL cholesterol levels ( 32203549) Lipid metabolism phenotypes ( 19936222) Lipid traits ( 24386095 24023260) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Liver fat content (MRI proton density fat fraction measure) ( 32247823) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte counts ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 22399527 30382898 31589552) Metabolic syndrome (multivariate analysis) ( 29632305) Metabolic traits ( 19060910 21886157) Metabolite levels ( 21909109 22286219 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 22558069) Non-oily fish consumption ( 32066663) Nonalcoholic fatty liver disease ( 29385134) Nonalcoholic steatohepatitis ( 32298765) Palmitic acid (16:0) levels ( 23362303) Palmitoleic acid (16:1n-7) levels ( 28298293 23362303) Percent glycated albumin ( 29844224) Phospholipid levels (plasma) ( 22359512) Plasma lactate levels ( 26433129) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Platelet count ( 22139419 29403010 32888494 27863252) Plateletcrit ( 32888494 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Postprandial triglyceride levels ( 32603185) Problematic alcohol use ( 32451486) Protein C levels ( 28082259) Prothrombin time ( 29403010) Red blood cell count ( 27863252) Red cell distribution width ( 32888494 27863252) Refractive error ( 32231278) Relative protein intake ( 32393786) Renal overload gout ( 27899376) Renal underexcretion gout ( 32238385 27899376) Resting heart rate ( 29769521 27798624) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum albumin level ( 23022100 29403010) Serum alkaline phosphatase levels ( 31666285) Serum alpha1-antitrypsin levels ( 26174136) Serum metabolite levels ( 31636271 23093944) Serum metabolite levels (CMS) ( 31636271) Serum total protein level ( 23022100 29403010) Serum uric acid levels ( 30993211 29403010) Sex hormone-binding globulin levels ( 22829776) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Total body bone mineral density ( 29304378) Total cholesterol levels ( 28334899 31087446 29403010 29615537 30275531) Total triglycerides levels ( 26690388) Triglyceride levels ( 30718733 28334899 31087446 31647587 32154731 30911093 29403010 29615537) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 23726366 24097068 29404214 21909109 18193043 18193044 20864672 26160806 19060906 19060911 20139978 30275531 17463246 25961943 26780889 20686565 26582766) Triglycerides-Blood Pressure (TG-BP) ( 21386085) Two-hour glucose challenge ( 20081857) Type 2 diabetes ( 28566273 22885922 30054458 30297969 29632382 26818947 32499647 30718926 28869590) Type 2 diabetes (adjusted for BMI) ( 29632382) Urate levels ( 31985003 20884846 31578528 20139978 23263486) Urate levels in obese individuals ( 25811787) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 19503597) Urinary albumin-to-creatinine ratio in diabetes ( 31511532) Urinary sodium excretion ( 31409800) Urinary sodium to creatinine ratio ( 30910378) Urolithiasis ( 30975718) Waist Circumference - Triglycerides (WC-TG) ( 21386085) Waist circumference and related phenotypes ( 18454146) White blood cell count ( 29403010 32888494 27863252 24777453)
Interacting Genes		6 interacting genes: GCKR INS PCNA PFKFB2 PFKFB3 SPDYE4	4 interacting genes: CDKN1A EP300 GCK TRAF2
Entrez ID		2645	2646
HPRD ID		00680	02909
Ensembl ID		ENSG00000106633	ENSG00000084734
Uniprot IDs		P35557 Q53Y25	A0A0C4DFN2 Q14397
PDB IDs		1GLK 1V4S 1V4T 3A0I 3F9M 3FGU 3FR0 3GOI 3H1V 3ID8 3IDH 3IMX 3QIC 3S41 3VEV 3VEY 3VF6 4DCH 4DHY 4ISE 4ISF 4ISG 4IWV 4IXC 4L3Q 4LC9 4MLE 4MLH 4NO7 4RCH 5V4W 5V4X 6E0E 6E0I	4BB9 4BBA 4LY9 4MQU 4MRO 4MSU 4OHK 4OHM 4OHO 4OHP 4OLH 4OP1 4OP2 4OP3 4PX2 4PX3 4PX5 4PXS
Enriched GO Terms of Interacting Partners?
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