MAP3K20 and VPS33B

Data Source:
BioGRID (two hybrid)

		MAP3K20	VPS33B
Description		mitogen-activated protein kinase kinase kinase 20	VPS33B late endosome and lysosome associated
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cytoplasm Lysosome Lysosomal Membrane Late Endosome Golgi Apparatus Clathrin-coated Vesicle HOPS Complex Platelet Alpha Granule Early Endosome Membrane Late Endosome Membrane CORVET Complex Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Magnesium Ion Binding RNA Binding Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding	Protein Binding Protein-containing Complex Binding
	Biological Process	DNA Damage Checkpoint Activation Of MAPKK Activity Protein Phosphorylation Cytoskeleton Organization Cell Cycle Arrest Activation Of JUN Kinase Activity Cell Death Cell Differentiation Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Stress-activated MAPK Cascade Limb Development Cellular Response To Gamma Radiation Positive Regulation Of Mitotic DNA Damage Checkpoint	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Endosome Organization Endosome To Lysosome Transport Protein Transport Vesicle-mediated Transport Peptidyl-lysine Hydroxylation Melanosome Localization Lysosome Localization Collagen Metabolic Process Membrane Fusion Platelet Alpha Granule Organization Autophagosome Maturation
Pathways			Prevention of phagosomal-lysosomal fusion
Drugs		Dasatinib Fostamatinib
Diseases			Arthrogryposis, renal dysfunction, and cholestasis; ARC syndrome
GWAS			Chronic kidney disease ( 30226566) Coronary artery disease ( 30402224) Feeling hurt ( 29500382) Hypertension ( 30226566) Ischemic stroke ( 29930801) Myocardial infarction ( 30226566) Red cell distribution width ( 32888494)
Interacting Genes		32 interacting genes: CCDC69 CRMP1 DDAH2 EZH2 IGHM ITSN1 MAP2K4 MAP2K6 MAP2K7 MIDN MPP1 NEDD4L RBX1 RNF19A RPS6KA5 SMARCB1 SRPK2 TGFBR1 UNC119 VPS33B YWHAG YWHAZ ZFP1 ZFP2 ZNF33A ZNF35 ZNF567 ZNF593 ZNF660 ZNF71 ZNF746 ZNF775	6 interacting genes: APP MAP3K20 MAPK8IP2 TNIP1 UVRAG VIPAS39
Entrez ID		51776	26276
HPRD ID		11791	10541
Ensembl ID		ENSG00000091436	ENSG00000184056
Uniprot IDs		D4Q8H0 Q9NYL2	A0A0S2Z577 B7Z1N4 F5H008 Q9H267
PDB IDs		5HES 5X5O 6JUT 6JUU
Enriched GO Terms of Interacting Partners?
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