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CDK5RAP1 and EXOSC5
Data Source:
BioGRID
(two hybrid)
CDK5RAP1
EXOSC5
Description
CDK5 regulatory subunit associated protein 1
exosome component 5
Image
No pdb structure
GO Annotations
Cellular Component
Cellular_component
Mitochondrion
Cytosol
Nuclear Exosome (RNase Complex)
Cytoplasmic Exosome (RNase Complex)
Exosome (RNase Complex)
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Transcriptionally Active Chromatin
Molecular Function
Protein Kinase Binding
N6-isopentenyladenosine Methylthiotransferase Activity
Protein-containing Complex Binding
Metal Ion Binding
4 Iron, 4 Sulfur Cluster Binding
3'-5'-exoribonuclease Activity
RNA Binding
Exoribonuclease Activity
Protein Binding
Biological Process
Brain Development
TRNA Methylthiolation
Regulation Of Neuron Differentiation
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Translational Fidelity
Positive Regulation Of Mitochondrial Translation
Mitochondrial TRNA Modification
RRNA Processing
RRNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
U4 SnRNA 3'-end Processing
Regulation Of MRNA Stability
Exonucleolytic Catabolism Of Deadenylated MRNA
DNA Deamination
Defense Response To Virus
Nuclear MRNA Surveillance
Polyadenylation-dependent SnoRNA 3'-end Processing
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways
ATF4 activates genes in response to endoplasmic reticulum stress
mRNA decay by 3' to 5' exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS
Diastolic blood pressure (
30224653
)
Hip circumference adjusted for BMI (
25673412
)
Mean corpuscular volume (
32888494
)
Interacting Genes
4 interacting genes:
CDK5
CDK5R1
EXOSC3
EXOSC5
80 interacting genes:
ACOT11
ADAMTSL4
BIRC2
BORCS6
CALCOCO2
CCDC88B
CDK5RAP1
DAAM2
DDIT4L
DHRS2
DIS3
DMRTB1
DOCK8
EFHC2
EXOSC1
EXOSC10
EXOSC2
EXOSC3
EXOSC6
EXOSC7
EXOSC8
EXOSC9
FCHO1
FH
FHL3
GOLGA2
HBS1L
HOXC4
IKZF3
KCTD13
KIAA1217
KRT13
KRT27
KRT31
KRT34
KRT35
LCA5L
LIPG
LRMDA
LSM3
LSM5
LZTS2
MEOX2
MPHOSPH6
MTMR3
MTREX
MYLIP
NKAPD1
NMI
NUP210
PA2G4
PALS2
PEG10
PICK1
PIH1D2
PKM
POLR2L
PRDM6
PTEN
REL
SFPQ
SH3GLB1
SH3GLB2
SHISA6
SNW1
SPTA1
TEX11
TFIP11
TLE5
TNFAIP1
TRIB3
TRIM54
TRIM62
ZFP90
ZMAT1
ZNF420
ZNF558
ZNF620
ZNF655
ZNF792
Entrez ID
51654
56915
HPRD ID
12189
16222
Ensembl ID
ENSG00000101391
ENSG00000077348
Uniprot IDs
A0A0S2Z592
A0A0S2Z5J9
Q53H36
Q96SZ6
Q9NQT4
PDB IDs
2NN6
6D6Q
6D6R
6H25
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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