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HDAC2 and EED
Data Source:
HPRD
(in vitro, in vivo, two hybrid)
HDAC2
EED
Description
histone deacetylase 2
embryonic ectoderm development
Image
GO Annotations
Cellular Component
Histone Deacetylase Complex
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Sin3 Complex
NuRD Complex
Protein-containing Complex
ESC/E(Z) Complex
Nucleus
Nucleoplasm
Chromosome
Cytosol
ESC/E(Z) Complex
Molecular Function
RNA Polymerase II Repressing Transcription Factor Binding
Chromatin Binding
RNA Binding
Histone Deacetylase Activity
Protein Binding
Transcription Factor Binding
Deacetylase Activity
Enzyme Binding
Heat Shock Protein Binding
Nucleosomal DNA Binding
NAD-dependent Histone Deacetylase Activity (H3-K14 Specific)
Protein Deacetylase Activity
Histone Deacetylase Binding
Sequence-specific DNA Binding
NF-kappaB Binding
Promoter-specific Chromatin Binding
RNA Polymerase II Transcription Corepressor Binding
Protein Binding
Nucleosome Binding
Histone Methyltransferase Activity
Identical Protein Binding
Histone Methyltransferase Activity (H3-K27 Specific)
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Response To Amphetamine
Cardiac Muscle Hypertrophy
Chromatin Remodeling
Blood Coagulation
Positive Regulation Of Cell Population Proliferation
Epidermal Cell Differentiation
Positive Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Neuron Projection Development
Dendrite Development
Histone Deacetylation
Response To Caffeine
Response To Lipopolysaccharide
Positive Regulation Of Interleukin-1 Production
Positive Regulation Of Tumor Necrosis Factor Production
Circadian Regulation Of Gene Expression
Positive Regulation Of Collagen Biosynthetic Process
Cellular Response To Heat
Response To Nicotine
Response To Cocaine
Odontogenesis Of Dentin-containing Tooth
Response To Drug
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Embryonic Digit Morphogenesis
ATP-dependent Chromatin Remodeling
Negative Regulation Of Apoptotic Process
Negative Regulation Of DNA Binding
Negative Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of MHC Class II Biosynthetic Process
Positive Regulation Of Proteolysis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Behavioral Response To Ethanol
Positive Regulation Of Oligodendrocyte Differentiation
Response To Hyperoxia
Hair Follicle Placode Formation
Negative Regulation Of Dendritic Spine Development
Eyelid Development In Camera-type Eye
Fungiform Papilla Formation
Cellular Response To Hydrogen Peroxide
Heterochromatin Maintenance
Histone H3 Deacetylation
Histone H4 Deacetylation
Cellular Response To Retinoic Acid
Cellular Response To Transforming Growth Factor Beta Stimulus
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Male Mating Behavior
Cellular Response To Dopamine
Positive Regulation Of Signaling Receptor Activity
Negative Regulation Of Peptidyl-lysine Acetylation
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Silencing
Viral Process
Negative Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of G0 To G1 Transition
Histone H3-K27 Methylation
Pathways
p75NTR negatively regulates cell cycle via SC1
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
Notch-HLH transcription pathway
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
SUMOylation of chromatin organization proteins
Regulation of TP53 Activity through Acetylation
RNA Polymerase I Transcription Initiation
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Regulation of MECP2 expression and activity
MECP2 regulates neuronal receptors and channels
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
EGR2 and SOX10-mediated initiation of Schwann cell myelination
EGR2 and SOX10-mediated initiation of Schwann cell myelination
Potential therapeutics for SARS
Factors involved in megakaryocyte development and platelet production
PRC2 methylates histones and DNA
Oxidative Stress Induced Senescence
PKMTs methylate histone lysines
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Transcriptional Regulation by E2F6
HCMV Early Events
Drugs
Pravastatin
Lovastatin
Theophylline
Valproic acid
Simvastatin
Atorvastatin
Fluvastatin
Aminophylline
Oxtriphylline
Vorinostat
Belinostat
Pracinostat
Romidepsin
Panobinostat
Tixocortol
Mocetinostat
Diseases
GWAS
Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy (
26460308
)
Metabolite levels (
23823483
)
Refractive error (
32231278
)
Smoking initiation (ever regular vs never regular) (
30679032
)
Smoking status (ever vs never smokers) (
30643258
)
Interacting Genes
96 interacting genes:
ANTXR1
APPL1
ARID4A
AURKA
BCL11A
BRCA1
BRMS1
BRMS1L
BUB3
CDC20
CDH1
CDKN1A
CDYL
CHFR
CIR1
CSNK2A1
CSNK2A2
CTBP1
CYTOR
DAXX
DDX20
DMAP1
DNMT1
DNMT3B
EED
EID2
ERCC6
FKBP3
GATA3
H2AC1
H2AC20
H2BC21
H3-4
H3C1
HDAC1
HDAC10
HDAC7
HIF1A
HIF1AN
HOPX
HUWE1
IFRD1
IKZF1
IKZF4
ING1
MAD1L1
MBD2
MBD3L2
MEN1
MTA1
MXD1
NACC2
NRIP1
PA2G4
PADI4
PHB2
PHF21A
PIAS4
PML
PPARD
PPP1R8
PTMA
RBBP4
RBBP7
RBP1
RCOR1
RELA
RFX5
RUNX3
SALL1
SAP30
SETDB1
SIN3A
SMAD2
SMARCA5
SMYD1
SNW1
SP1
SP3
SPEN
SS18L1
STAT3
SUMO2
SUV39H1
SYK
TFCP2
THRA
THRB
TOP2A
TOP2B
TP53
USP4
VHL
YY1
ZBTB16
ZNF461
42 interacting genes:
AEBP2
ANXA5
AR
BRCA1
CDK2AP2
CTSL
DNMT1
DNMT3A
DNMT3B
DUSP23
EHMT1
EPC2
EZH1
EZH2
FHL1
H1-1
H3C1
HDAC1
HDAC2
HDAC3
ITGA4
ITGAE
ITGB7
MAP1LC3B
NUDT21
PJA1
PPP1CA
PPP1R8
PRDM14
RACK1
RPS10
SELENBP1
SMYD3
SRPK2
TGS1
TRIM55
TRIM63
TSC22D1
UBE2W
YY1
ZBED8
ZFP42
Entrez ID
3066
8726
HPRD ID
05521
09343
Ensembl ID
ENSG00000196591
ENSG00000074266
Uniprot IDs
Q92769
E9PJK2
O75530
PDB IDs
3MAX
4LXZ
4LY1
5IWG
5IX0
6G3O
6WBW
6WBZ
6XDM
6XEB
6XEC
3IIW
3IIY
3IJ0
3IJ1
3IJC
3JPX
3JZG
3JZH
3JZN
3K26
3K27
4W2R
4X3E
5GSA
5H13
5H14
5H15
5H17
5H19
5H24
5H25
5HYN
5IJ7
5IJ8
5K0M
5LS6
5TTW
5U5H
5U5K
5U5T
5U62
5U69
5U6D
5U8A
5U8F
5WG6
5WP3
5WUK
6B3W
6C23
6C24
6SFB
6SFC
6U4Y
6W7F
6W7G
Enriched GO Terms of Interacting Partners
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