RAB6B and RABGAP1

Data Source:
HPRD (two hybrid)

		RAB6B	RABGAP1
Description		RAB6B, member RAS oncogene family	RAB GTPase activating protein 1
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GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol Endomembrane System Cytoplasmic Vesicle Presynapse	Centrosome Cytosol Microtubule Associated Complex
	Molecular Function	GTPase Activity Protein Binding GTP Binding Myosin V Binding	GTPase Activator Activity Protein Binding Tubulin Binding Small GTPase Binding
	Biological Process	Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intra-Golgi Vesicle-mediated Transport Retrograde Transport, Endosome To Golgi	Intracellular Protein Transport Cell Cycle Regulation Of GTPase Activity Activation Of GTPase Activity Regulation Of Cilium Assembly
Pathways		COPI-independent Golgi-to-ER retrograde traffic Retrograde transport at the Trans-Golgi-Network TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	TBC/RABGAPs
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Immune reponse to smallpox (secreted IL-1beta) ( 22610502) Iron status biomarkers (total iron binding capacity) ( 28334935) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Post bronchodilator FEV1/FVC ratio ( 26634245)	Birth weight ( 31043758) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Pulse pressure ( 27841878 30578418) Systolic blood pressure ( 27841878)
Interacting Genes		14 interacting genes: ACVR1 BICD2 BMPR1B COG6 ERC1 KIF20A LNX2 MEOX2 PMM1 RABGAP1 RAP1GDS1 SH2B2 SMAD1 TGFBR1	10 interacting genes: CARM1 DISC1 GABARAPL1 MAP1LC3A RAB4A RAB6A RAB6B SENP1 SENP5 STAT3
Entrez ID		51560	23637
HPRD ID		11474	06575
Ensembl ID		ENSG00000154917	ENSG00000011454
Uniprot IDs		Q9NRW1	Q9Y3P9
PDB IDs		2E9S 2FE4 2FFQ	4NC6
Enriched GO Terms of Interacting Partners?
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