COL5A1 and SPARC

Data Source:
BioGRID (pull down)

		COL5A1	SPARC
Description		collagen type V alpha 1 chain	secreted protein acidic and cysteine rich
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GO Annotations	Cellular Component	Extracellular Region Collagen Type V Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix	Extracellular Region Basement Membrane Extracellular Space Cytoplasm Mitochondrion Plasma Membrane Cell Surface Nuclear Matrix Platelet Alpha Granule Platelet Alpha Granule Membrane Platelet Alpha Granule Lumen Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Endocytic Vesicle Lumen Glutamatergic Synapse
	Molecular Function	Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Heparin Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Proteoglycan Binding Metal Ion Binding Platelet-derived Growth Factor Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Collagen Binding Extracellular Matrix Binding
	Biological Process	Blood Vessel Development Heart Morphogenesis Cell Adhesion Cell Migration Extracellular Matrix Organization Collagen Fibril Organization Collagen Biosynthetic Process Wound Healing, Spreading Of Epidermal Cells Tendon Development Skin Development Integrin Biosynthetic Process Eye Morphogenesis Regulation Of Cellular Component Organization Supramolecular Fiber Organization Negative Regulation Of Endodermal Cell Differentiation	Ossification Negative Regulation Of Endothelial Cell Proliferation Platelet Degranulation Receptor-mediated Endocytosis Heart Development Response To Gravity Response To Lead Ion Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Regulation Of Cell Morphogenesis Extracellular Matrix Organization Lung Development Response To Lipopolysaccharide Response To L-ascorbic Acid Response To Cytokine Wound Healing Response To Peptide Hormone Response To Ethanol Response To Cadmium Ion Inner Ear Development Anatomical Structure Development Regulation Of Synapse Organization Response To Glucocorticoid Response To CAMP Response To Calcium Ion
Pathways		Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization	Platelet degranulation Nuclear signaling by ERBB4 ECM proteoglycans Scavenging by Class H Receptors
Drugs			Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases		Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
GWAS		Blood pressure ( 24954895) Central corneal thickness ( 32528159 28171582 22814818 31798171 23493294 29760442 30894546 20719862) Corneal structure ( 23291589) Crohn's disease (need for surgery) ( 23665963) Intraocular pressure ( 29617998) Longevity ( 20834067) Metabolite levels ( 23823483) Phosphatidylcholine levels ( 31551469) Refractive error ( 32231278)
Interacting Genes		10 interacting genes: BMP1 COL5A3 DCN LGALS3BP MAG PDGFA PDGFB SDC3 SPARC THBS1	22 interacting genes: COL13A1 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 CPEB2 CTSK FN1 HSPG2 PDGFA PDGFB PLAT PLG SDC2 TGFB1 TGM2 THBS1 UBQLN1 VEGFA XRCC6 ZNF579
Entrez ID		1289	6678
HPRD ID		00368	01631
Ensembl ID		ENSG00000130635	ENSG00000113140
Uniprot IDs		A0A024R8E5 B2ZZ86 P20908 Q59EE7	P09486
PDB IDs		1A89 1A9A	1BMO 1NUB 1SRA 2V53
Enriched GO Terms of Interacting Partners?
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