TMEM14C and CLDN5

Data Source:
BioGRID (two hybrid)

		TMEM14C	CLDN5
Description		transmembrane protein 14C	claudin 5
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrial Inner Membrane Integral Component Of Membrane Mitochondrial Membrane	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Integral Component Of Membrane Apicolateral Plasma Membrane Cell Junction Cortical Actin Cytoskeleton Tight Junction
	Molecular Function	Protein Binding	Structural Molecule Activity Protein Binding Identical Protein Binding
	Biological Process	Heme Biosynthetic Process Mitochondrial Transport Erythrocyte Differentiation Regulation Of Heme Biosynthetic Process	Outflow Tract Morphogenesis Cell-cell Junction Assembly Cell Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Learning Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Negative Regulation Of Angiogenesis Negative Regulation Of Cell Migration Positive Regulation Of Protein Binding Maintenance Of Blood-brain Barrier Negative Regulation Of Vascular Permeability Roof Of Mouth Development Face Morphogenesis Bicellular Tight Junction Assembly Tight Junction Assembly Positive Regulation Of Establishment Of Endothelial Barrier Positive Regulation Of Bicellular Tight Junction Assembly Establishment Of Blood-retinal Barrier Regulation Of Bicellular Tight Junction Assembly
Pathways			Tight junction interactions RUNX1 regulates expression of components of tight junctions
Drugs
Diseases
GWAS		Itch intensity from mosquito bite adjusted by bite size ( 28199695) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261)
Interacting Genes		45 interacting genes: ARL13B BCL2L13 BIK CLDN5 COMT COQ9 CPLANE2 CREB3 CREB3L1 CYB5R3 EBP ELOVL7 FAM209A GJB1 GORAB GPR152 HSD17B13 KASH5 LMNA LNX1 MARCHF8 MFF MMGT1 MTERF3 MUC1 NCAPH2 NCR3LG1 PDZK1IP1 PLIN3 RCHY1 SDC3 SLC10A6 SSMEM1 STX1A SYT1 TMEM14B TMEM31 TMEM35A TMEM52B TMEM79 TMEM86B TMX2 VSIR ZDHHC15 ZFYVE27	40 interacting genes: AQP1 BTNL8 CCDC167 CLDN3 CLRN2 CNPY3 CORIN CTRL CXCL9 CYB561A3 EFNA5 EHHADH ERG28 ERMP1 FXYD6-FXYD2 GYPA LAT LHFPL5 MIP MPDZ PLP2 PLPPR2 PMP22 RPRM SFTPC SGCG SLC35B4 SMIM3 TECR TF TJP1 TMEM128 TMEM140 TMEM14C TMEM182 TMEM190 TMEM222 TSPAN2 VAMP5 YIPF1
Entrez ID		51522	7122
HPRD ID		15524	03654
Ensembl ID		ENSG00000111843	ENSG00000184113
Uniprot IDs		A0A024R001 Q9P0S9	D3DX19 O00501
PDB IDs		2LOS
Enriched GO Terms of Interacting Partners?
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