LARS1 and MIR15A

Data Source:
BioGRID (unspecified method)

		LARS1	MIR15A
Description		leucyl-tRNA synthetase 1	microRNA 15a
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Endoplasmic Reticulum Cytosol Endomembrane System Nuclear Body Aminoacyl-tRNA Synthetase Multienzyme Complex	Extracellular Space Extracellular Exosome Extracellular Vesicle
	Molecular Function	Aminoacyl-tRNA Editing Activity Glutamine-tRNA Ligase Activity Leucine-tRNA Ligase Activity GTPase Activator Activity Protein Binding ATP Binding	MRNA 3'-UTR Binding MRNA Binding Involved In Posttranscriptional Gene Silencing
	Biological Process	TRNA Aminoacylation For Protein Translation Glutaminyl-tRNA Aminoacylation Leucyl-tRNA Aminoacylation Regulation Of Cell Size Positive Regulation Of TOR Signaling Cellular Response To Amino Acid Starvation Positive Regulation Of GTPase Activity Cellular Response To Amino Acid Stimulus Cellular Response To Leucine Aminoacyl-tRNA Metabolism Involved In Translational Fidelity Positive Regulation Of TORC1 Signaling Cellular Response To Leucine Starvation	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cell Population Proliferation Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Angiogenesis Negative Regulation Of NF-kappaB Transcription Factor Activity Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Positive Regulation Of Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Inflammatory Response Cellular Response To Glucose Stimulus Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Cell Chemotaxis To Fibroblast Growth Factor Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Selenoamino acid metabolism Cytosolic tRNA aminoacylation
Drugs		Leucine
Diseases
GWAS
Interacting Genes		55 interacting genes: CDC42 EEF1G ESR1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR128-1 MIR128-2 MIR138-2 MIR15A MIR15B MIR17 MIR18A MIR18B MIR199A1 MIR19B1 MIR19B2 MIR200A MIR205 MIR206 MIR20B MIR21 MIR214 MIR221 MIR25 MIR29A MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR451A MIR7-1 MIR7-2 MIR9-1 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I SUMO2	73 interacting genes: AIMP1 AIMP2 C1QBP CPSF1 DARS1 DDX1 DDX21 DDX3X DDX49 DHX36 DHX37 EIF2AK2 EPRS1 ERAL1 FAM98A FUS HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI2 MYEF2 NOL6 NONO NUDT21 PDCD11 PGAM5 PLOD1 PRMT1 PTBP1 PUF60 QARS1 RARS1 RBM14 RTCA RTCB SF3A1 SF3B1 SF3B2 SF3B3 SFPQ SPOUT1 SYNCRIP TAF15 TRA2A TRA2B TRIM71 TRMT10C UPF1 UTP20 YBX1 YBX3 ZNF346
Entrez ID		51520	406948
HPRD ID		01042
Ensembl ID		ENSG00000133706	ENSG00000283785
Uniprot IDs		A0A6I8PL42 B4DER1 B4E266 Q9P2J5
PDB IDs		2WFD 6LPF 6LR6
Enriched GO Terms of Interacting Partners?
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