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RAD51 and RAD18
Data Source:
BioGRID
(affinity chromatography technology, pull down)
RAD51
RAD18
Description
RAD51 recombinase
RAD18 E3 ubiquitin protein ligase
Image
GO Annotations
Cellular Component
Nuclear Chromosome
Chromosome, Telomeric Region
Chromatin
Condensed Chromosome
Condensed Nuclear Chromosome
Lateral Element
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Microtubule Organizing Center
PML Body
Protein-containing Complex
Site Of Double-strand Break
Perinuclear Region Of Cytoplasm
Nucleus
Nucleoplasm
Replication Fork
Cytoplasm
Centrosome
Nuclear Body
Site Of Double-strand Break
Nuclear Inclusion Body
Rad6-Rad18 Complex
Molecular Function
Recombinase Activity
Chromatin Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
DNA-dependent ATPase Activity
Single-stranded DNA Helicase Activity
Enzyme Binding
Identical Protein Binding
DNA Polymerase Binding
Y-form DNA Binding
Damaged DNA Binding
Single-stranded DNA Binding
Protein Binding
Polyubiquitin Modification-dependent Protein Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Protein-containing Complex Binding
Metal Ion Binding
Biological Process
Telomere Maintenance Via Recombination
Double-strand Break Repair Via Homologous Recombination
DNA Recombinase Assembly
Regulation Of Protein Phosphorylation
DNA Unwinding Involved In DNA Replication
DNA Repair
DNA Recombination
Mitotic Recombination
Cellular Response To DNA Damage Stimulus
Reciprocal Meiotic Recombination
Response To Toxic Substance
Response To X-ray
Regulation Of Double-strand Break Repair Via Homologous Recombination
Telomere Maintenance Via Telomere Lengthening
Replication Fork Processing
Interstrand Cross-link Repair
Strand Invasion
Response To Drug
Positive Regulation Of DNA Ligation
Meiotic Cell Cycle
Chromosome Organization Involved In Meiotic Cell Cycle
Negative Regulation Of G0 To G1 Transition
Cellular Response To Ionizing Radiation
Cellular Response To Gamma Radiation
Cellular Response To Hydroxyurea
Cellular Response To Cisplatin
Cellular Response To Camptothecin
Response To Glucoside
Replication-born Double-strand Break Repair Via Sister Chromatid Exchange
Mitotic Recombination-dependent Replication Fork Processing
DNA Repair
Postreplication Repair
Protein Monoubiquitination
Cellular Response To DNA Damage Stimulus
Response To UV
Protein Ubiquitination
DNA Damage Response, Detection Of DNA Damage
Protein Autoubiquitination
Positive Regulation Of Chromosome Segregation
Negative Regulation Of Cell Death
Pathways
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Presynaptic phase of homologous DNA pairing and strand exchange
Transcriptional Regulation by E2F6
Meiotic recombination
Recognition of DNA damage by PCNA-containing replication complex
E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Phosphoaminophosphonic Acid-Adenylate Ester
Amuvatinib
Diseases
GWAS
Anxiety and stress-related disorders (
31116379
)
Malaria (
31844061
)
Mean spheric corpuscular volume (
32888494
)
Refractive error (
32231278
)
Chronotype (
30696823
)
Clopidogrel active metabolite levels (
28207573
)
Metabolite levels (
23823483
)
Morning person (
30696823
)
Sleep duration (
30531941
)
Transverse temporal cortex volume (
31530798
)
Interacting Genes
94 interacting genes:
-
ABL1
AGO2
ATM
ATRX
BARD1
BCCIP
BCR
BLM
BRCA1
BRCA2
C1orf112
CASP3
CASP7
CCND1
CDH13
CHD3
CHEK1
CSNK2A1
CSNK2B
CST6
CTCF
DDB2
DMC1
DNAJA3
ENAH
EP400
ERCC2
ERCC5
EVL
FANCD2
FANCI
FBH1
FIGNL1
HID1
HNRNPC
HSP90AA1
IL24
IRS1
ITIH5
MAPK8IP3
MDC1
MMS22L
MND1
MSH4
NBN
NCL
NELFB
NXF1
PALB2
PARPBP
PCSK1N
PDS5B
PFN1
PLK1
POLA1
RAD18
RAD51AP1
RAD51AP2
RAD51B
RAD51C
RAD52
RAD54B
RAD54L
RECQL5
RELA
RFWD3
RPA1
RPA2
RPA3
SEM1
SFR1
SIRT2
ST14
SUMO1
SUMO2
SWSAP1
TFF1
TP53
TP53BP1
UBE2I
UCHL3
UGDH
UHRF2
UMPS
USP10
VASP
VIM
WDR48
WRN
XPO1
XRCC2
XRCC3
ZDHHC17
30 interacting genes:
ARRDC3
DAZAP2
DZIP3
GOLGA2
MAGEA4
MAP3K1
MAPK8
MLKL
NBN
ORC2
PCGF6
PCNA
PDCD5
POLK
RAD51
RFC2
SHPRH
SIVA1
TAX1BP1
TP53BP1
TRIM23
TRIM8
TSG101
UBC
UBE2A
UBE2B
UBE2D2
UBE2I
USP2
USP7
Entrez ID
5888
56852
HPRD ID
01557
09242
Ensembl ID
ENSG00000051180
ENSG00000070950
Uniprot IDs
Q06609
Q9NS91
PDB IDs
1B22
1N0W
5H1B
5H1C
5JZC
5NP7
5NWL
2MRE
2MRF
2Y43
2YBF
5VF0
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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