Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
RAD51 and NBN
Data Source:
BioGRID
(far western blotting)
RAD51
NBN
Description
RAD51 recombinase
nibrin
Image
GO Annotations
Cellular Component
Nuclear Chromosome
Chromosome, Telomeric Region
Chromatin
Condensed Chromosome
Condensed Nuclear Chromosome
Lateral Element
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Microtubule Organizing Center
PML Body
Protein-containing Complex
Site Of Double-strand Break
Perinuclear Region Of Cytoplasm
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Replication Fork
Nucleolus
Cytosol
PML Body
Mre11 Complex
Site Of Double-strand Break
Nuclear Inclusion Body
Molecular Function
Recombinase Activity
Chromatin Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
DNA-dependent ATPase Activity
Single-stranded DNA Helicase Activity
Enzyme Binding
Identical Protein Binding
DNA Polymerase Binding
Damaged DNA Binding
Protein Binding
Transcription Factor Binding
Protein N-terminus Binding
Biological Process
Telomere Maintenance Via Recombination
Double-strand Break Repair Via Homologous Recombination
DNA Recombinase Assembly
Regulation Of Protein Phosphorylation
DNA Unwinding Involved In DNA Replication
DNA Repair
DNA Recombination
Mitotic Recombination
Cellular Response To DNA Damage Stimulus
Reciprocal Meiotic Recombination
Response To Toxic Substance
Response To X-ray
Regulation Of Double-strand Break Repair Via Homologous Recombination
Telomere Maintenance Via Telomere Lengthening
Replication Fork Processing
Interstrand Cross-link Repair
Strand Invasion
Response To Drug
Positive Regulation Of DNA Ligation
Meiotic Cell Cycle
Chromosome Organization Involved In Meiotic Cell Cycle
Negative Regulation Of G0 To G1 Transition
Cellular Response To Ionizing Radiation
Cellular Response To Gamma Radiation
Cellular Response To Hydroxyurea
Cellular Response To Cisplatin
Cellular Response To Camptothecin
Response To Glucoside
Replication-born Double-strand Break Repair Via Sister Chromatid Exchange
Mitotic Recombination-dependent Replication Fork Processing
DNA Damage Checkpoint
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Double-strand Break Processing
Blastocyst Growth
DNA Replication
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
Cell Cycle Arrest
Mitotic G2 DNA Damage Checkpoint
Cell Population Proliferation
Viral Process
Regulation Of DNA-dependent DNA Replication Initiation
DNA Damage Response, Signal Transduction By P53 Class Mediator
Telomeric 3' Overhang Formation
Positive Regulation Of Protein Autophosphorylation
Positive Regulation Of Telomere Maintenance
DNA Duplex Unwinding
Positive Regulation Of Kinase Activity
Signal Transduction In Response To DNA Damage
Isotype Switching
Neuromuscular Process Controlling Balance
Meiotic Cell Cycle
T-circle Formation
Telomere Maintenance Via Telomere Trimming
Intrinsic Apoptotic Signaling Pathway
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Telomere Capping
Pathways
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Presynaptic phase of homologous DNA pairing and strand exchange
Transcriptional Regulation by E2F6
Meiotic recombination
DNA Damage/Telomere Stress Induced Senescence
HDR through Single Strand Annealing (SSA)
HDR through MMEJ (alt-NHEJ)
HDR through Homologous Recombination (HRR)
Sensing of DNA Double Strand Breaks
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Meiotic recombination
Drugs
Phosphoaminophosphonic Acid-Adenylate Ester
Amuvatinib
Diseases
DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS
Anxiety and stress-related disorders (
31116379
)
Malaria (
31844061
)
Mean spheric corpuscular volume (
32888494
)
Refractive error (
32231278
)
Lymphocyte counts (
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Monocyte count (
32888494
)
Interacting Genes
94 interacting genes:
-
ABL1
AGO2
ATM
ATRX
BARD1
BCCIP
BCR
BLM
BRCA1
BRCA2
C1orf112
CASP3
CASP7
CCND1
CDH13
CHD3
CHEK1
CSNK2A1
CSNK2B
CST6
CTCF
DDB2
DMC1
DNAJA3
ENAH
EP400
ERCC2
ERCC5
EVL
FANCD2
FANCI
FBH1
FIGNL1
HID1
HNRNPC
HSP90AA1
IL24
IRS1
ITIH5
MAPK8IP3
MDC1
MMS22L
MND1
MSH4
NBN
NCL
NELFB
NXF1
PALB2
PARPBP
PCSK1N
PDS5B
PFN1
PLK1
POLA1
RAD18
RAD51AP1
RAD51AP2
RAD51B
RAD51C
RAD52
RAD54B
RAD54L
RECQL5
RELA
RFWD3
RPA1
RPA2
RPA3
SEM1
SFR1
SIRT2
ST14
SUMO1
SUMO2
SWSAP1
TFF1
TP53
TP53BP1
UBE2I
UCHL3
UGDH
UHRF2
UMPS
USP10
VASP
VIM
WDR48
WRN
XPO1
XRCC2
XRCC3
ZDHHC17
35 interacting genes:
ATF2
ATM
ATR
BAP1
BRCA1
CASC3
CCNE1
CDK9
CHEK2
DCLRE1C
EP300
FANCD2
H2AX
H3-4
HIF1A
MDC1
MRE11
NAT2
NCL
PRKDC
RAD18
RAD50
RAD51
RECQL5
SIRT1
SNAI1
SUMO2
TERF1
TLK1
TREX1
UBE2D1
UBE2N
VRK1
XRCC4
XRCC5
Entrez ID
5888
4683
HPRD ID
01557
04050
Ensembl ID
ENSG00000051180
ENSG00000104320
Uniprot IDs
Q06609
A0A0C4DG07
O60934
PDB IDs
1B22
1N0W
5H1B
5H1C
5JZC
5NP7
5NWL
5WQD
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?