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SNX9 and WAS
Data Source:
BioGRID
(pull down)
SNX9
WAS
Description
sorting nexin 9
WASP actin nucleation promoting factor
Image
GO Annotations
Cellular Component
Ruffle
Cytoplasm
Trans-Golgi Network
Cytosol
Plasma Membrane
Clathrin-coated Vesicle
Cytoplasmic Vesicle Membrane
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Cytoplasmic Vesicle
Cuticular Plate
Extracellular Exosome
Nucleus
Cytosol
Actin Filament
Plasma Membrane
Cell-cell Junction
Vesicle Membrane
Actin Cytoskeleton
Site Of Double-strand Break
Phagocytic Vesicle
Extracellular Exosome
Molecular Function
Protein Binding
1-phosphatidylinositol Binding
Ubiquitin Protein Ligase Binding
Phosphatidylinositol Binding
Identical Protein Binding
Protein Homodimerization Activity
Cadherin Binding
Arp2/3 Complex Binding
Actin Binding
Protein Binding
SH3 Domain Binding
Protein Kinase Binding
GTPase Regulator Activity
Small GTPase Binding
Identical Protein Binding
Phospholipase Binding
Biological Process
Mitotic Cytokinesis
Intracellular Protein Transport
Endocytosis
Receptor-mediated Endocytosis
Endosomal Transport
Positive Regulation Of Actin Filament Polymerization
Cleavage Furrow Formation
Positive Regulation Of GTPase Activity
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Membrane Protein Ectodomain Proteolysis
Lipid Tube Assembly
Membrane Organization
Protein-containing Complex Assembly
Plasma Membrane Tubulation
Regulation Of T Cell Antigen Processing And Presentation
Defense Response
Immune Response
Rho Protein Signal Transduction
Blood Coagulation
Regulation Of Actin Polymerization Or Depolymerization
Actin Polymerization Or Depolymerization
Epidermis Development
Regulation Of Lamellipodium Assembly
Endosomal Transport
Actin Filament Polymerization
Actin Filament-based Movement
Cdc42 Protein Signal Transduction
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
T Cell Activation
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Catalytic Activity
T Cell Receptor Signaling Pathway
Regulation Of Stress Fiber Assembly
Negative Regulation Of Stress Fiber Assembly
Protein-containing Complex Assembly
Cellular Response To Interferon-gamma
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Negative Regulation Of Cell Motility
Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways
Golgi Associated Vesicle Biogenesis
Clathrin-mediated endocytosis
Generation of second messenger molecules
Regulation of actin dynamics for phagocytic cup formation
Regulation of actin dynamics for phagocytic cup formation
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate WASPs and WAVEs
FCGR3A-mediated phagocytosis
FCGR3A-mediated phagocytosis
Drugs
(S)-wiskostatin
Diseases
Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
GWAS
Borderline personality disorder (
28632202
)
Heart rate response to beta blockers (
29478026
)
Lipoprotein (a) - cholesterol levels (
25575512
)
Metabolite levels (
23823483
)
Platelet distribution width (
32888494
27863252
)
Platelet distribution width (
32888494
)
Interacting Genes
23 interacting genes:
ADAM15
ADAM9
AP1G1
CLTC
DAPK1
DNM1
DNM2
EGFR
FASLG
ITCH
KHDRBS1
LRRK1
MPHOSPH6
PAK2
PALS2
PI4KA
PIK3CA
PIK3R5
SOS1
SOS2
TNK2
WAS
WASL
56 interacting genes:
ABI3
ACTC1
APBB1
APPBP2
ARHGAP1
ARHGEF7
ARPC1B
ARPC2
ARPC3
BAIAP2L1
BTK
C5AR1
CDC42
CIB1
CRKL
CSNK2A1
CSNK2A2
DLG1
DVL2
ENAH
EVL
FCHSD2
FGR
FYB1
FYN
GRB2
HCK
HCLS1
ITK
ITSN2
LCK
LCP2
NCK1
NCK2
NCKIPSD
PIK3R1
PLCG1
PRPF40A
PSTPIP1
PTPN12
RAC1
RANBP2
RGS14
RHOJ
SNX9
SORBS2
SRC
TCERG1
TEC
TNK2
TRIP10
UBASH3A
VASP
WBP4
WIPF1
WIPF2
Entrez ID
51429
7454
HPRD ID
12072
02314
Ensembl ID
ENSG00000130340
ENSG00000015285
Uniprot IDs
Q9Y5X1
A0A024QYX8
P42768
PDB IDs
2RAI
2RAJ
2RAK
3DYT
3DYU
3LGE
1CEE
1EJ5
1T84
2A3Z
2K42
2OT0
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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