PRKAG2 and PRKAB2

Data Source:
HPRD (two hybrid)

		PRKAG2	PRKAB2
Description		protein kinase AMP-activated non-catalytic subunit gamma 2	protein kinase AMP-activated non-catalytic subunit beta 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Nucleotide-activated Protein Kinase Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Nucleotide-activated Protein Kinase Complex
	Molecular Function	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding ATP Binding CAMP-dependent Protein Kinase Regulator Activity Phosphorylase Kinase Regulator Activity AMP Binding Protein Kinase Regulator Activity Protein Kinase Binding Protein Kinase Activator Activity ADP Binding	AMP-activated Protein Kinase Activity Protein Binding Protein Kinase Binding Identical Protein Binding
	Biological Process	Glycogen Metabolic Process Regulation Of Glycolytic Process Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Fatty Acid Biosynthetic Process ATP Biosynthetic Process Carnitine Shuttle Cell Cycle Arrest Positive Regulation Of Peptidyl-threonine Phosphorylation Sterol Biosynthetic Process Macroautophagy Regulation Of Macroautophagy Regulation Of Fatty Acid Metabolic Process Activation Of Protein Kinase Activity Intracellular Signal Transduction Cellular Response To Glucose Starvation Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Protein Kinase Activity Regulation Of Fatty Acid Oxidation Regulation Of Glucose Import Regulation Of Catalytic Activity Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of CAMP-dependent Protein Kinase Activity	Protein Phosphorylation Fatty Acid Biosynthetic Process Carnitine Shuttle Cell Cycle Arrest Signal Transduction Macroautophagy Regulation Of Macroautophagy Regulation Of Fatty Acid Biosynthetic Process Regulation Of Catalytic Activity Regulation Of Primary Metabolic Process Positive Regulation Of Cold-induced Thermogenesis Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Carnitine metabolism Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs	Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Carnitine metabolism Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs
Drugs		Adenosine phosphate Acetylsalicylic acid Fostamatinib	Adenosine phosphate Acetylsalicylic acid Fostamatinib
Diseases		Hypertrophic cardiomyopathy (HCM)
GWAS		Bipolar disorder (age of onset and psychotic symptoms) ( 21305692) Blood urea nitrogen levels ( 31152163) Brain morphology (MOSTest) ( 32665545) Chronic kidney disease ( 31152163 26831199 20383146) Creatinine levels ( 31015462) Diastolic blood pressure ( 27841878) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 29891935) Glomerular filtration rate ( 27588450) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in diabetes ( 29703844) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Glomerular filtration rate in type 2 diabetes ( 29703844) Gut microbiota (beta diversity) ( 27723756) Hematocrit ( 32888494 27863252 28017375 19862010) Hemoglobin ( 32888494 19862010) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693 28017375) Intraocular pressure ( 29785010 31959993) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Metabolite levels (small molecules and protein measures) ( 27005778) Pulse pressure ( 27841878 30578418) Red blood cell count ( 32888494 28453575 27863252) Red blood cell traits ( 23222517) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878 27618447 30578418) Urate levels ( 31578528 23263486) Urea levels ( 31015462 28270201) Urinary albumin excretion ( 32277301)
Interacting Genes		5 interacting genes: DAPK1 MFHAS1 PRKAB1 PRKAB2 PRKAG1	170 interacting genes: ABHD11 ADAMTSL4 ANAPC11 ARID5A AUNIP AVP BANP BEND5 BHLHB9 BLZF1 C11orf1 C19orf54 C2orf42 C3orf36 CALCOCO2 CASP2 CASP6 CCDC28B CCDC33 CDC14B CDSN CDX4 CFP CREB3L1 CRX CSNK2B CYSRT1 DAO DDAH2 DDIT4L DICER1 DOK3 DST ELL2 EPM2A ESM1 FDX1 FLNC GATA1 GATAD2B GCSAML GET4 GOLGA2 GOLGA6L9 GORASP2 GRAPL GRN GSC2 IHO1 IKZF1 IKZF3 IL37 IRAK1BP1 KATNBL1 KCTD5 KHDC4 KLF15 KRBOX4 KRT31 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP3-3 KRTAP4-12 KRTAP4-2 KRTAP4-5 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LHX3 LRIF1 LZTS1 LZTS2 MAGED1 MAJIN MDFI MEOX2 METTL27 MORN3 NAB2 NEBL NHLRC4 NUTM1 OXER1 PDE6G PDE6H PFDN5 PIAS2 PNMA1 PPP1R13B PPP1R16A PRDM14 PRKAA1 PRKAG1 PRKAG2 PSMD11 PSME3 PYGM QKI RAB3IP RACK1 RBM48 RBPMS REL RHEBL1 RIMBP3 RNF144B ROR2 RPH3AL SAMD4A SERTAD2 SMARCB1 SMUG1 SPRY1 SPRY2 SSC4D SSX2IP STX11 STX19 TADA2A TASOR2 TCF12 TCF19 TCF4 TCF7L2 TGM7 TLE5 TNNI1 TP53 TP53BP2 TRAF1 TRAF2 TRIB3 TRIM10 TRIM14 TRIM35 TRIM42 TRIM54 TRIM55 TRIM63 TSR2 TTC23 UBXN11 USP54 VBP1 VPS28 WDR83 YPEL3 YY1AP1 ZBTB32 ZC2HC1C ZFP90 ZMYND19 ZNF177 ZNF236 ZNF474 ZNF526 ZNF559-ZNF177 ZNF581
Entrez ID		51422	5565
HPRD ID		04119	04117
Ensembl ID		ENSG00000106617	ENSG00000131791
Uniprot IDs		A0A090N8Q6 A0A384MDZ2 A0A494C068 A0A494C1K7 B7Z6X8 E9PGP6 Q9UGJ0	O43741
PDB IDs			2F15 2V8Q 2V92 2V9J 2Y8L 2Y8Q 2YA3 4CFH 4EAI 4EAJ 4RER 4REW 6B2E
Enriched GO Terms of Interacting Partners?
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