HEMK1 and SHOX

Data Source:
BioGRID (two hybrid)

		HEMK1	SHOX
Description		HemK methyltransferase family member 1	short stature homeobox
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion	Chromatin Nucleus Nucleoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding Protein Binding N-methyltransferase Activity Protein Methyltransferase Activity Protein-(glutamine-N5) Methyltransferase Activity	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA Methylation Protein Methylation	Skeletal System Development Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases			SHOX-related haploinsufficiency disorders, including: Isolated short stature; Langer syndrome; Leri-Weill syndrome
GWAS		Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Cocaine dependence ( 31212010) Depressive symptom (appetite changes) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331) Height ( 28552196)
Interacting Genes		18 interacting genes: AKAP8L ASCL3 CDC23 CHN1 CTAG1A CTAG1B HEATR9 INCA1 KRTAP19-1 MAGED1 PEF1 POU2AF1 PSMB4 SHOX SOHLH1 SPRYD7 TUBGCP5 UBQLN2	5 interacting genes: CSNK2A1 GLIS2 HEMK1 IGBP1 NKX2-5
Entrez ID		51409	6473
HPRD ID		13645	02430
Ensembl ID		ENSG00000114735	ENSG00000185960
Uniprot IDs		A0A140VK98 B2RA37 Q9Y5R4	A0A024R385 O15266
PDB IDs
Enriched GO Terms of Interacting Partners?
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