TRAPPC4 and SDC2

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		TRAPPC4	SDC2
Description		trafficking protein particle complex subunit 4	syndecan 2
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GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Golgi Stack Cytosol Synaptic Vesicle TRAPP Complex Dendrite Synapse Postsynaptic Membrane	Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Integral Component Of Membrane Lysosomal Lumen Collagen-containing Extracellular Matrix
	Molecular Function	Protein Binding	Protein Binding PDZ Domain Binding Identical Protein Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Autophagy Dendrite Development COPII Vesicle Coating	Retinoid Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Biological_process Cell Migration Post-translational Protein Modification Cellular Protein Metabolic Process Ephrin Receptor Signaling Pathway Dendrite Morphogenesis Regulation Of Dendrite Morphogenesis Leukocyte Migration
Pathways		COPII-mediated vesicle transport Syndecan interactions RAB GEFs exchange GTP for GDP on RABs	A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPHB-mediated forward signaling Defective B3GALT6 causes EDSP2 and SEMDJL1 Post-translational protein phosphorylation Retinoid metabolism and transport
Drugs		S-palmitoyl-L-cysteine	Sargramostim
Diseases
GWAS			Post-traumatic stress disorder ( 26114229) Refractive error ( 32231278)
Interacting Genes		10 interacting genes: APP PRSS23 SDC2 TFIP11 TRAPPC11 TRAPPC12 TRAPPC2 TRAPPC2L TRAPPC3L TRAPPC8	28 interacting genes: ANOS1 ASPH BAG6 CASK CSF2 CYP2C18 EPHB2 EZR FGF2 FN1 HGF ITGB4 LAMA3 NF1 PF4 PPP3CC PRKCA PRKCB PRKCG REG3A SDCBP SERPINA1 SERPINC1 SPARC TGFB1 TGFBR3 TNFSF13 TRAPPC4
Entrez ID		51399	6383
HPRD ID		18220	00803
Ensembl ID		ENSG00000196655	ENSG00000169439
Uniprot IDs		B4DF86 E9PKS9 E9PQE8 J3KP27 Q9Y296	A0A024R9D1 E9PBI9 P34741
PDB IDs		2J3T 2JSN 2ZMV	6ITH
Enriched GO Terms of Interacting Partners?
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