SDC2 and ANOS1

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		SDC2	ANOS1
Description		syndecan 2	anosmin 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Integral Component Of Membrane Lysosomal Lumen Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Extracellular Matrix
	Molecular Function	Protein Binding PDZ Domain Binding Identical Protein Binding	Serine-type Endopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent Protein Binding Heparin Binding
	Biological Process	Retinoid Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Biological_process Cell Migration Post-translational Protein Modification Cellular Protein Metabolic Process Ephrin Receptor Signaling Pathway Dendrite Morphogenesis Regulation Of Dendrite Morphogenesis Leukocyte Migration	Chemotaxis Cell Adhesion Axon Guidance Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Endopeptidase Activity Neuron Differentiation
Pathways		A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPHB-mediated forward signaling Defective B3GALT6 causes EDSP2 and SEMDJL1 Post-translational protein phosphorylation Retinoid metabolism and transport	FGFR1c ligand binding and activation Negative regulation of FGFR1 signaling
Drugs		Sargramostim
Diseases			Hypogonadotropic hypogonadism; Kallmann syndrome (KAL)
GWAS		Post-traumatic stress disorder ( 26114229) Refractive error ( 32231278)	Estimated glomerular filtration rate ( 31015462)
Interacting Genes		28 interacting genes: ANOS1 ASPH BAG6 CASK CSF2 CYP2C18 EPHB2 EZR FGF2 FN1 HGF ITGB4 LAMA3 NF1 PF4 PPP3CC PRKCA PRKCB PRKCG REG3A SDCBP SERPINA1 SERPINC1 SPARC TGFB1 TGFBR3 TNFSF13 TRAPPC4	6 interacting genes: FGFR2 FGFR3 FN1 NCALD SDC2 UBQLN1
Entrez ID		6383	3730
HPRD ID		00803	02393
Ensembl ID		ENSG00000169439	ENSG00000011201
Uniprot IDs		A0A024R9D1 E9PBI9 P34741	P23352
PDB IDs		6ITH	1ZLG
Enriched GO Terms of Interacting Partners?
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