COMMD10 and SCNN1A

Data Source:
BioGRID (pull down)

		COMMD10	SCNN1A
Description		COMM domain containing 10	sodium channel epithelial 1 subunit alpha
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm	Acrosomal Vesicle Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane Motile Cilium Sodium Channel Complex Ciliary Membrane Extracellular Exosome Sperm Principal Piece
	Molecular Function	Protein Binding	Protein Binding Ligand-gated Sodium Channel Activity WW Domain Binding
	Biological Process		Ion Transmembrane Transport Sodium Ion Transmembrane Transport Multicellular Organismal Water Homeostasis Response To Stimulus Sensory Perception Of Taste Sodium Ion Homeostasis
Pathways		Neddylation	Stimuli-sensing channels
Drugs			Triamterene Amiloride
Diseases			Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome) Bronchiectasis with or without elevated sweat chloride
GWAS		Ankle-brachial index ( 31388106) Asthma or chronic obstructive pulmonary disease ( 24993907) Bipolar disorder and schizophrenia ( 22688191) Inflammatory biomarkers ( 22228203) Metabolite levels (X-11787) ( 23934736)	Adverse response to drug ( 30420678) Alopecia areata ( 25608926) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Obesity (early onset extreme) ( 23563609) Primary biliary cirrhosis ( 22961000)
Interacting Genes		5 interacting genes: COMMD1 COMMD5 SCNN1A SCNN1B SCNN1G	17 interacting genes: COMMD10 CSNK2A1 EPN1 HECW1 ITCH NEDD4 NEDD4L SCNN1B SCNN1G SERP1 SNX3 STX1A TSG101 UBE2I USP10 WWP1 WWP2
Entrez ID		51397	6337
HPRD ID		16734	02575
Ensembl ID		ENSG00000145781	ENSG00000111319
Uniprot IDs		D6RJ90 Q9Y6G5	P37088
PDB IDs			2M3O 6BQN 6WTH
Enriched GO Terms of Interacting Partners?
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