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SCNN1A and STX1A
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo, in vitro)
SCNN1A
STX1A
Description
sodium channel epithelial 1 subunit alpha
syntaxin 1A
Image
No pdb structure
GO Annotations
Cellular Component
Acrosomal Vesicle
Cytoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
Apical Plasma Membrane
Motile Cilium
Sodium Channel Complex
Ciliary Membrane
Extracellular Exosome
Sperm Principal Piece
Extracellular Region
Cytosol
Plasma Membrane
Synaptic Vesicle
Voltage-gated Potassium Channel Complex
Endomembrane System
Postsynaptic Density
Integral Component Of Membrane
Secretory Granule
Integral Component Of Synaptic Vesicle Membrane
Axon
SNARE Complex
Nuclear Membrane
Actomyosin
Neuron Projection
Presynaptic Active Zone Membrane
Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex
Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex
Synaptobrevin 2-SNAP-25-syntaxin-1a Complex
Glutamatergic Synapse
Integral Component Of Presynaptic Membrane
Molecular Function
Protein Binding
Ligand-gated Sodium Channel Activity
WW Domain Binding
SNARE Binding
SNAP Receptor Activity
Protein Binding
Calcium Channel Inhibitor Activity
Chloride Channel Inhibitor Activity
Kinase Binding
Protein Domain Specific Binding
Myosin Head/neck Binding
Identical Protein Binding
ATP-dependent Protein Binding
Ion Channel Binding
Protein-containing Complex Binding
Protein N-terminus Binding
Calcium-dependent Protein Binding
Biological Process
Ion Transmembrane Transport
Sodium Ion Transmembrane Transport
Multicellular Organismal Water Homeostasis
Response To Stimulus
Sensory Perception Of Taste
Sodium Ion Homeostasis
Positive Regulation Of Neurotransmitter Secretion
Intracellular Protein Transport
Exocytosis
Vesicle Fusion
Neurotransmitter Secretion
Response To Gravity
Positive Regulation Of Norepinephrine Secretion
Regulation Of Synaptic Vesicle Priming
Glutamate Secretion
Synaptic Vesicle Exocytosis
Synaptic Vesicle Docking
Protein Sumoylation
Calcium-ion Regulated Exocytosis
Cytokine-mediated Signaling Pathway
Insulin Secretion
Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane
Secretion By Cell
Positive Regulation Of Catecholamine Secretion
SNARE Complex Assembly
Positive Regulation Of Calcium Ion-dependent Exocytosis
Vesicle Docking
Synaptic Vesicle Endocytosis
Regulation Of Insulin Secretion
Protein Localization To Membrane
Positive Regulation Of Excitatory Postsynaptic Potential
Pathways
Stimuli-sensing channels
Serotonin Neurotransmitter Release Cycle
Norepinephrine Neurotransmitter Release Cycle
Glutamate Neurotransmitter Release Cycle
Dopamine Neurotransmitter Release Cycle
Acetylcholine Neurotransmitter Release Cycle
Insulin processing
Regulation of insulin secretion
Other interleukin signaling
Toxicity of botulinum toxin type C (botC)
LGI-ADAM interactions
Neurexins and neuroligins
GABA synthesis, release, reuptake and degradation
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Triamterene
Amiloride
Diseases
Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
Bronchiectasis with or without elevated sweat chloride
GWAS
Adverse response to drug (
30420678
)
Alopecia areata (
25608926
)
Itch intensity from mosquito bite adjusted by bite size (
28199695
)
Obesity (early onset extreme) (
23563609
)
Primary biliary cirrhosis (
22961000
)
Malaria (
31844061
)
Triglyceride levels (
32203549
)
Interacting Genes
17 interacting genes:
COMMD10
CSNK2A1
EPN1
HECW1
ITCH
NEDD4
NEDD4L
SCNN1B
SCNN1G
SERP1
SNX3
STX1A
TSG101
UBE2I
USP10
WWP1
WWP2
167 interacting genes:
AARD
ABCC9
ABI3
AGTRAP
AIG1
ANKRD46
AOC3
APBA1
APOL2
APOL3
AQP3
ARL13B
ATP4B
ATP6V1B1
BET1
BLOC1S6
BNIP1
BTN2A2
C1GALT1
C4orf3
CACNA1D
CCSER2
CD81
CDC37
CDK5
CFTR
CLEC1A
CLN6
CMTM7
CPLX1
CSNK2A1
CSNK2A2
CXCL16
CYB5B
DAPK1
DDX49
EBAG9
EMD
ERG28
ETNK2
FAM3C
GIMAP1
GIMAP5
GOLM2
GOSR2
GPM6B
HMOX1
JAGN1
KCNB1
KIFC3
MAL
MALL
MIP
MMGT1
NAPA
NAPB
NINJ2
NKG7
NRM
NSF
PGAP2
PLN
PLP1
PLPP4
PLPP6
PNLIPRP1
PSMA3
RAB27A
RAB3IL1
RIMS1
RMDN2
RNF4
RTP2
SCNN1A
SCNN1B
SCNN1G
SDCBP
SEC22A
SEC22B
SEPTIN2
SEPTIN5
SERP1
SERP2
SLC6A1
SLC6A2
SLC6A3
SLC6A4
SLC6A5
SLC6A9
SMIM1
SMIM3
SNAP23
SNAP25
SNAP29
SNAP47
SNORC
SNPH
STRIT1
STX10
STX11
STX12
STX16
STX2
STX3
STX4
STX5
STX6
STX7
STX8
STXBP1
STXBP2
STXBP5
STXBP6
SUMO1P1
SYT1
SYT4
SYT7
SYTL4
TCEANC
TMEM100
TMEM120A
TMEM128
TMEM14C
TMEM199
TMEM222
TMEM254
TMEM41A
TMEM60
TNF
TRAF3IP3
TRDMT1
TSGA10IP
TSNARE1
TXLNA
TXLNB
UBE2I
UBTFL1
UNC13B
UPK1B
USE1
VAMP1
VAMP2
VAMP3
VAMP4
VAMP5
VAMP7
VAMP8
VAPB
VIM
VPS11
VPS16
VPS18
VSTM4
VTI1B
ZFPL1
ZNF12
ZNF136
ZNF250
ZNF440
ZNF441
ZNF479
ZNF490
ZNF557
ZNF696
ZNF707
ZNF785
ZNF835
Entrez ID
6337
6804
HPRD ID
02575
01721
Ensembl ID
ENSG00000111319
ENSG00000106089
Uniprot IDs
P37088
Q16623
Q75ME0
PDB IDs
2M3O
6BQN
6WTH
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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