C1RL and HP

Data Source:
HPRD (in vitro)

		C1RL	HP
Description		complement C1r subcomponent like	haptoglobin
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Haptoglobin-hemoglobin Complex Specific Granule Lumen Extracellular Exosome Endocytic Vesicle Lumen Blood Microparticle Tertiary Granule Lumen
	Molecular Function	Serine-type Endopeptidase Activity	Serine-type Endopeptidase Activity Protein Binding Antioxidant Activity Hemoglobin Binding
	Biological Process	Complement Activation, Classical Pathway Zymogen Activation Innate Immune Response	Acute Inflammatory Response Receptor-mediated Endocytosis Defense Response Acute-phase Response Positive Regulation Of Cell Death Zymogen Activation Response To Hydrogen Peroxide Defense Response To Bacterium Neutrophil Degranulation Negative Regulation Of Oxidoreductase Activity Cellular Oxidant Detoxification Negative Regulation Of Hydrogen Peroxide Catabolic Process
Pathways			Scavenging of heme from plasma Neutrophil degranulation
Drugs			Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Night sleep phenotypes ( 27126917)	Blood protein levels ( 29875488 28240269) Cholesterol, total ( 25961943 20686565) Haptoglobin levels ( 22403646) Hemoglobin levels ( 32327693) LDL cholesterol ( 25961943 20686565) Low density lipoprotein cholesterol levels ( 29403010) Metabolite levels ( 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Morning person ( 30696823) Parental lifespan ( 30642433) Plasma haptoglobin levels in type 2 diabetes ( 29572449) Total cholesterol levels ( 29403010) Urinary haptoglobin levels in type 2 diabetes ( 29572449)
Interacting Genes		2 interacting genes: HP SPP1	21 interacting genes: ADAMTS4 APOA1 ATP7B C1RL CD163 CD22 GADD45G GRB2 HBB ITGAM ITGB2 LAMC3 MVP RBBP6 RPL11 SMAD3 TBL1X TGM2 TP63 VKORC1 WASL
Entrez ID		51279	3240
HPRD ID		07093	00772
Ensembl ID		ENSG00000139178	ENSG00000257017
Uniprot IDs		F5GWF3 F5H7C8 Q6P672 Q9NZP8	A0A0C4DGL8 P00738 Q6PEJ8
PDB IDs			4WJG 4X0L 5HU6 6TB2
Enriched GO Terms of Interacting Partners?
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Tagcloud (Intersection) ?