CDKL3 and KASH5

Data Source:
BioGRID (two hybrid)

		CDKL3	KASH5
Description		cyclin dependent kinase like 3	KASH domain containing 5
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GO Annotations	Cellular Component	Nucleus Cytoplasm	Chromosome, Telomeric Region Lateral Element Nuclear Outer Membrane Integral Component Of Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Meiotic Spindle Pole
	Molecular Function	Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Protein Binding Identical Protein Binding Dynein Complex Binding
	Biological Process	Cellular Protein Modification Process Protein Phosphorylation Negative Regulation Of Axon Extension Positive Regulation Of Dendrite Morphogenesis Regulation Of Cell Cycle Dendrite Extension	Double-strand Break Repair Via Homologous Recombination Actin Filament Organization Homologous Chromosome Pairing At Meiosis Spermatogenesis Telomere Localization Oogenesis Spindle Assembly Spindle Localization Microtubule Cytoskeleton Organization Involved In Homologous Chromosome Segregation Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation
Pathways
Drugs
Diseases
GWAS		Eosinophil counts ( 27863252) Moderate-to-late spontaneous preterm birth ( 31194736)
Interacting Genes		31 interacting genes: APP ATG4A CYSRT1 DISC1 DNAAF6 FXR1 FXR2 GGA1 GOLGA2 IKZF1 KANK2 KASH5 KRTAP10-9 LRP2BP LRRK2 LZTS2 MCC MDFI MTUS2 PICK1 PIH1D2 RABEP1 SNRNP70 SRPK1 TRIM27 TRIM37 TTF2 ZBTB14 ZBTB43 ZBTB8A ZRANB1	112 interacting genes: ABHD1 ADIPOQ ANKRD46 ATF7 BAG5 BCL2L2 BET1 C14orf180 CCDC120 CCDC87 CDC73 CDKL3 CIB3 CLDN8 CMTM5 CRABP2 CTXN3 CWF19L2 CXCL16 CXCL9 CYBC1 DERL1 DNAJC30 EFNA5 EMD FAM161A FAM241B FAM50B FAM90A1 FATE1 FIS1 FRA10AC1 FTCD FXYD3 GABARAPL2 GALNT2 GIMAP5 GOSR2 GPATCH4 GPR25 HMOX1 ITGAM ITM2B JAGN1 KDM1A LARP1 LAT LENG1 LHFPL5 LMNA LRCH4 MALL MARCHF2 MFSD5 MMP14 MOSPD3 MS4A1 MTX2 NRIP3 NSG1 NTAQ1 OLFM4 PDGFRA PGAP2 PGRMC1 PIGU PLP2 PLPP6 PPP1R18 RIPPLY2 RNF146 RSPH14 RSRC2 RTP2 SENP2 SERP2 SGTA SHMT2 SLC30A2 SLC35B4 SLC41A1 SLC41A2 SLC5A4 SLN SMCO4 SNAP47 STBD1 STX12 STX5 TCF25 TMEM11 TMEM147 TMEM14C TMEM19 TMEM199 TMEM41A TMEM86A TMPRSS4 TNF TRAF3IP3 TRARG1 TSHZ3 TTC23 UPK1B UPK2 VAMP1 VAMP2 VAMP4 VTI1B ZC2HC1C ZFPL1 ZNF250
Entrez ID		51265	147872
HPRD ID		09766	08134
Ensembl ID		ENSG00000006837	ENSG00000161609
Uniprot IDs		B4DX41 Q8IVW4	Q8N6L0
PDB IDs		3ZDU	6R2I
Enriched GO Terms of Interacting Partners?
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