PAIP2 and UBR5

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		PAIP2	UBR5
Description		poly(A) binding protein interacting protein 2	ubiquitin protein ligase E3 component n-recognin 5
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GO Annotations	Cellular Component	Cytoplasm	Nucleus Nucleoplasm Cytosol Membrane Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Translation Repressor Activity, MRNA Regulatory Element Binding MRNA Binding Protein Binding Translation Repressor Activity	RNA Binding Protein Binding Zinc Ion Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Binding Ubiquitin Protein Ligase Activity
	Biological Process	Spermatogenesis Memory Negative Regulation Of Translation Negative Regulation Of Translational Initiation Regulation Of Long-term Synaptic Potentiation	Protein Polyubiquitination DNA Repair Cellular Response To DNA Damage Stimulus Positive Regulation Of Gene Expression Viral Process Positive Regulation Of Protein Import Into Nucleus Progesterone Receptor Signaling Pathway Protein K48-linked Ubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Histone H2A K63-linked Ubiquitination Regulation Of Double-strand Break Repair Negative Regulation Of Double-strand Break Repair
Pathways
Drugs
Diseases
GWAS		Body mass index ( 26426971) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Malaria ( 31844061)	Chromosomal aberration frequency (total) ( 31586183) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Rate of cognitive decline in mild cognitive impairment (time interaction) ( 22833209) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		7 interacting genes: APP ELAVL1 PABPC1 PABPC5 RPL11 TRIM54 UBR5	30 interacting genes: BARD1 CIB1 CSPP1 DYRK2 ERG GSK3B KPNA1 KPNA2 KPNB1 MAPK1 MOAP1 NR1I2 OTUD5 PAIP1 PAIP2 PCK1 PGR SATB1 SMAD2 SOX2 TCEA1 TOPBP1 TXNIP UBC UBE2A UBE2B UBE2D2 UBE2D3 UBE2L3 ZNF207
Entrez ID		51247	51366
HPRD ID		05726	06436
Ensembl ID		ENSG00000120727	ENSG00000104517
Uniprot IDs		Q49AE6 Q9BPZ3	O95071
PDB IDs		1JGN 3KUS 3KUT	1I2T 2QHO 3PT3
Enriched GO Terms of Interacting Partners?
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