PLCE1 and LIMS1

Data Source:
BioGRID (two hybrid)

		PLCE1	LIMS1
Description		phospholipase C epsilon 1	LIM zinc finger domain containing 1
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GO Annotations	Cellular Component	Golgi Membrane Cytosol Plasma Membrane Lamellipodium	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Enzyme Binding Small GTPase Binding Metal Ion Binding	Protein Binding Zinc Ion Binding Protein Kinase Binding Protein-containing Complex Binding
	Biological Process	Activation Of MAPK Activity Regulation Of Cell Growth Diacylglycerol Biosynthetic Process Regulation Of Smooth Muscle Contraction Cytoskeleton Organization Epidermal Growth Factor Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Ras Protein Signal Transduction Heart Development Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Lamellipodium Assembly Lipid Catabolic Process Calcium-mediated Signaling Glomerulus Development Inositol Phosphate Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Ras Protein Signal Transduction Phosphatidylinositol-mediated Signaling Inositol Phosphate-mediated Signaling	Epithelial To Mesenchymal Transition Cell Aging Positive Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Tumor Necrosis Factor-mediated Signaling Pathway Cell Junction Assembly Positive Regulation Of GTPase Activity Establishment Of Protein Localization Cell-cell Junction Organization Negative Regulation Of Transcription, DNA-templated Regulation Of Epithelial Cell Proliferation Positive Regulation Of Focal Adhesion Assembly Cellular Response To Transforming Growth Factor Beta Stimulus Cell-cell Adhesion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Integrin-mediated Signaling Pathway
Pathways		Synthesis of IP3 and IP4 in the cytosol	Cell-extracellular matrix interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Drugs
Diseases		Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		Birth weight ( 31043758) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Coronary artery disease ( 29212778) Dengue shock syndrome ( 22001756) Diastolic blood pressure ( 27841878 21909115 27618452) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Esophageal cancer ( 21642993) Esophageal cancer and gastric cancer ( 20729852) Esophageal squamous cell carcinoma ( 25129146) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 29891935) Glucose homeostasis traits ( 25524916) Hypertension ( 31879980 21909115) Lifetime average cigarettes per day in chronic obstructive pulmonary disease ( 21685187) Lymphocyte counts ( 32888494) Mean platelet volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Migraine ( 27182965 27322543) Monocyte count ( 32888494) Offspring birth weight ( 31043758) Optic cup area ( 31798171) Personality traits in bipolar disorder ( 21368711) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Platelet reactivity in response to clopidogrel treatment ( 32472697) Plateletcrit ( 32888494 27863252) Pulse pressure ( 27841878 28739976 30578418) Response to (pegylated) interferon in chronic hepatitis B ( 30715261) Sudden cardiac arrest ( 21658281) Systolic blood pressure ( 27841878 21909115 28739976 27618452 30578418) Vertical cup-disc ratio ( 31798171 25241763) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500) White blood cell count ( 32888494)	Apolipoprotein B levels ( 32203549) Beard thickness ( 26926045) Birth weight ( 31043758) Excessive hairiness ( 29895819) Eyebrow thickness ( 26926045) Immature fraction of reticulocytes ( 32888494) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Monobrow thickness ( 26926045) Scalp hair shape ( 26926045)
Interacting Genes		5 interacting genes: HRAS KIT LIMS1 NRAS PPP1R3B	47 interacting genes: ADAMTS9 ATXN10 CATSPER1 CCN2 COL8A1 CSRP3 CWF19L2 DAPK1 EHMT2 FAM90A1 FERMT2 FERMT3 FMR1 GEM ILK INO80B IPO7 KPRP LMO3 LPXN MBIP MYO15B NCK2 NEB OSR2 PARVA PEG3 PLCE1 RAD51D RBBP8 RSU1 SCNM1 SMURF1 TBC1D22B TCEA2 TGFBR1 TMSB4X TRIO TTN USP11 ZIM2 ZMYM4 ZNF160 ZNF410 ZNF417 ZNF564 ZNF587
Entrez ID		51196	3987
HPRD ID		07087	03978
Ensembl ID		ENSG00000138193	ENSG00000169756
Uniprot IDs		B7ZM61 Q9P212	P48059
PDB IDs		2BYE 2BYF 2C5L	1G47 1NYP 1U5S 2COR 2D8X 2KBX 3F6Q 4HI8 4HI9 6MIF
Enriched GO Terms of Interacting Partners?
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