LIMS1 and TRIO

Data Source:
BioGRID (two hybrid)

		LIMS1	TRIO
Description		LIM zinc finger domain containing 1	trio Rho guanine nucleotide exchange factor
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Protein-containing Complex Perinuclear Region Of Cytoplasm	Cytosol Cell Projection
	Molecular Function	Protein Binding Zinc Ion Binding Protein Kinase Binding Protein-containing Complex Binding	Protein Serine/threonine Kinase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Epithelial To Mesenchymal Transition Cell Aging Positive Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Tumor Necrosis Factor-mediated Signaling Pathway Cell Junction Assembly Positive Regulation Of GTPase Activity Establishment Of Protein Localization Cell-cell Junction Organization Negative Regulation Of Transcription, DNA-templated Regulation Of Epithelial Cell Proliferation Positive Regulation Of Focal Adhesion Assembly Cellular Response To Transforming Growth Factor Beta Stimulus Cell-cell Adhesion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Integrin-mediated Signaling Pathway	Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Axon Guidance Central Nervous System Development Positive Regulation Of Apoptotic Process Negative Regulation Of Fat Cell Differentiation Neuron Projection Morphogenesis Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Cell-extracellular matrix interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	NRAGE signals death through JNK Rho GTPase cycle G alpha (q) signalling events G alpha (12/13) signalling events DCC mediated attractive signaling DCC mediated attractive signaling
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Beard thickness ( 26926045) Birth weight ( 31043758) Excessive hairiness ( 29895819) Eyebrow thickness ( 26926045) Immature fraction of reticulocytes ( 32888494) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Monobrow thickness ( 26926045) Scalp hair shape ( 26926045)	Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel) ( 24025145) Antidepressant treatment resistance (number of drugs prescribed) ( 30700811) Asthma ( 31959851) Asthma (childhood onset) ( 31036433) Electroencephalogram traits ( 25387704) High density lipoprotein cholesterol levels ( 30498476) Intake of total sugars ( 31005972) Major depressive disorder ( 27777418) Paclitaxel-induced neuropathy ( 23776197) Physiological dysregulation (Mahalanobis distance) ( 32235003) Waist circumference ( 28552196)
Interacting Genes		47 interacting genes: ADAMTS9 ATXN10 CATSPER1 CCN2 COL8A1 CSRP3 CWF19L2 DAPK1 EHMT2 FAM90A1 FERMT2 FERMT3 FMR1 GEM ILK INO80B IPO7 KPRP LMO3 LPXN MBIP MYO15B NCK2 NEB OSR2 PARVA PEG3 PLCE1 RAD51D RBBP8 RSU1 SCNM1 SMURF1 TBC1D22B TCEA2 TGFBR1 TMSB4X TRIO TTN USP11 ZIM2 ZMYM4 ZNF160 ZNF410 ZNF417 ZNF564 ZNF587	13 interacting genes: BLMH CDC42 CDC5L DISC1 EXOC1 FLNA ITSN2 LIMS1 MAPRE1 PTK2 PTPRF RAC1 RHOA
Entrez ID		3987	7204
HPRD ID		03978	03537
Ensembl ID		ENSG00000169756	ENSG00000038382
Uniprot IDs		P48059	O75962
PDB IDs		1G47 1NYP 1U5S 2COR 2D8X 2KBX 3F6Q 4HI8 4HI9 6MIF	1NTY 2NZ8 6D8Z
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?