IPO11 and EIF4A2

Data Source:
BioGRID (two hybrid, proximity labelling technology)

		IPO11	EIF4A2
Description		importin 11	eukaryotic translation initiation factor 4A2
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Nucleoplasm Cytosol	Cytosol Eukaryotic Translation Initiation Factor 4F Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Nuclear Import Signal Receptor Activity	RNA Binding RNA Helicase Activity Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding ATPase Activity
	Biological Process	Protein Import Into Nucleus Ribosomal Protein Import Into Nucleus	Cytoplasmic Translational Initiation Translational Initiation Regulation Of Translational Initiation Viral Process Negative Regulation Of RNA-directed 5'-3' RNA Polymerase Activity Cellular Response To Leukemia Inhibitory Factor
Pathways			ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Alcohol and nicotine co-dependence ( 23216389) Diffusing capacity of the lung for carbon monoxide traits ( 30049742) General risk tolerance (MTAG) ( 30643258) Interstitial lung abnormalities ( 31339356) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Subpleural-predominant interstitial lung abnormalities ( 31339356)
Interacting Genes		12 interacting genes: C1orf94 EIF4A2 KEAP1 KRT76 NXF1 PLCD4 RAN RPL12 TRAF2 UBE2E1 UBE2E2 UBE2E3	23 interacting genes: BRCA1 CLNS1A DPPA4 ECT2 EIF4G1 EIF4G2 GOLGA2 HSPB2 IPO11 LINC01554 MCPH1 MDFI NEK2 PDCD4 PFDN1 PIH1D2 SLC16A9 SSX2IP SUMO2 TK1 TRIM36 TRIM39 ZNF620
Entrez ID		51194	1974
HPRD ID		10003	03062
Ensembl ID		ENSG00000086200	ENSG00000156976
Uniprot IDs		Q9UI26	Q14240
PDB IDs			3BOR
Enriched GO Terms of Interacting Partners?
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