HERC5 and IRF3

Data Source:
BioGRID (enzymatic study)

		HERC5	IRF3
Description		HECT and RLD domain containing E3 ubiquitin protein ligase 5	interferon regulatory factor 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Perinuclear Region Of Cytoplasm	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding ISG15 Transferase Activity Ubiquitin Protein Ligase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Polyubiquitination Protein Ubiquitination Protein Phosphopantetheinylation ISG15-protein Conjugation Negative Regulation Of Type I Interferon Production Innate Immune Response Regulation Of Defense Response To Virus Defense Response To Virus	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Regulation Of Transcription By RNA Polymerase II Apoptotic Process Cellular Response To DNA Damage Stimulus Viral Process Lipopolysaccharide-mediated Signaling Pathway Regulation Of Type I Interferon Production Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production TRIF-dependent Toll-like Receptor Signaling Pathway MDA-5 Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Exogenous DsRNA Macrophage Apoptotic Process Programmed Necrotic Cell Death Cellular Response To Virus
Pathways		ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation	ISG15 antiviral mechanism IRF3 mediated activation of type 1 IFN IRF3 mediated activation of type 1 IFN LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Regulation of innate immune responses to cytosolic DNA IRF3-mediated induction of type I IFN Interferon gamma signaling TICAM1-dependent activation of IRF3/IRF7 Interferon alpha/beta signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Negative regulators of DDX58/IFIH1 signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Drugs
Diseases
GWAS		Pulmonary function decline ( 22424883) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Autoimmune thyroid disease ( 32581359) Schizophrenia ( 29483656) Vitiligo ( 27723757)
Interacting Genes		15 interacting genes: BECN1 CCNA2 CCNB1 CCND1 CCNE1 CDKN1A ERCC2 IRF3 MTDH NME2 PITX2 STK38 UBE2D1 UBE2D2 UBE2L6	30 interacting genes: CREBBP EP300 EWSR1 FBXO7 GRIP1 HERC5 HSP90AA1 IKBKE IRF5 IRF7 MAPK8 MAVS PEX19 PIAS4 PPIB PRDX1 RB1 RBL1 RELA SERPINB2 SGTA SMURF2 SYT1 TBK1 TICAM1 TICAM2 TOMM70 TRIM26 TRIM55 TRIM63
Entrez ID		51191	3661
HPRD ID		10502	04769
Ensembl ID		ENSG00000138646	ENSG00000126456
Uniprot IDs		B4DXV3 Q9UII4	E2GIM5 E2GIM6 E2GIM7 E2GIM8 E2GIM9 M0QYT9 Q14653
PDB IDs			1J2F 1QWT 1T2K 1ZOQ 2O61 2O6G 2PI0 3A77 3QU6 5JEJ 5JEK 5JEL 5JEM 5JEO 5JER 6SIV 6SJA 7JFL
Enriched GO Terms of Interacting Partners?
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