DCXR and RPTOR

Data Source:
BioGRID (proximity labelling technology)

		DCXR	RPTOR
Description		dicarbonyl and L-xylulose reductase	regulatory associated protein of MTOR complex 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasmic Microtubule Plasma Membrane Microvillus Brush Border Extracellular Exosome	Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Cytoplasmic Stress Granule Dendrite TORC1 Complex Neuronal Cell Body
	Molecular Function	Carbonyl Reductase (NADPH) Activity Protein Binding Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Identical Protein Binding L-xylulose Reductase (NAD+) Activity L-xylulose Reductase (NADP+) Activity	RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding TFIIIC-class Transcription Factor Complex Binding Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Protein Kinase Activator Activity Protein-macromolecule Adaptor Activity Protein-containing Complex Binding 14-3-3 Protein Binding
	Biological Process	Xylulose Metabolic Process Glucose Metabolic Process NADP Metabolic Process Glucuronate Catabolic Process To Xylulose 5-phosphate D-xylose Metabolic Process	Regulation Of Cell Growth Positive Regulation Of Endothelial Cell Proliferation Cell Cycle Arrest Regulation Of Cell Size Cellular Response To Starvation Regulation Of Autophagy Positive Regulation Of Peptidyl-threonine Phosphorylation Viral Process Regulation Of Macroautophagy Positive Regulation Of Cell Growth Cellular Response To Nutrient Levels TOR Signaling Positive Regulation Of TOR Signaling Activation Of Protein Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation TORC1 Signaling Positive Regulation Of Transcription By RNA Polymerase III Cellular Response To Amino Acid Stimulus Cellular Response To Leucine Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cellular Response To Heat Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Formation of xylulose-5-phosphate Essential pentosuria	Macroautophagy MTOR signalling mTORC1-mediated signalling HSF1-dependent transactivation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs		Dihydrogenphosphate Nicotinamide adenine dinucleotide phosphate
Diseases		Pentosuria
GWAS		Refractive error ( 32231278)	Adult body size ( 32376654) Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Body mass index ( 28892062 25673413) Body size at age 10 ( 32376654) Hypertension ( 30487518) Mean arterial pressure ( 30487518) NASH resolution in nonalcoholic steatohepatitis ( 31832568) Nicotine dependence symptom count ( 25555482) Obesity ( 23563607) Pulse pressure ( 29403010 30487518) Systolic blood pressure ( 30487518)
Interacting Genes		3 interacting genes: APP CRADD GLRX2	23 interacting genes: CILK1 DUXAP9 EIF4EBP1 EIF4EBP2 IRS1 IRS2 LINC00839 MAPK1 MAPK3 MARK4 MLST8 MTOR NRBF2 PLD2 PRKAA1 PRKAA2 RAP1B RHEB RPS6KA1 RPS6KB1 RRAGA RRAGB WIPI2
Entrez ID		51181	57521
HPRD ID		16320	06184
Ensembl ID		ENSG00000169738	ENSG00000141564
Uniprot IDs		A0A384NY14 Q7Z4W1	Q6DKI0 Q8N122
PDB IDs		1PR9 1WNT 3D3W	5H64 6BCU 6BCX 6SB0 6SB2 6U62
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?