NAGPA and EPS15

Data Source:
HPRD (in vitro)

		NAGPA	EPS15
Description		N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase	epidermal growth factor receptor pathway substrate 15
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Membrane Golgi Cisterna Membrane	Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Basal Plasma Membrane Membrane Aggresome Apical Plasma Membrane Clathrin Coat Of Coated Pit Early Endosome Membrane Intracellular Membrane-bounded Organelle Postsynapse Glutamatergic Synapse
	Molecular Function	N-acetylglucosamine-1-phosphodiester Alpha-N-acetylglucosaminidase Activity Protein Binding	Calcium Ion Binding Protein Binding SH3 Domain Binding Polyubiquitin Modification-dependent Protein Binding Cadherin Binding
	Biological Process	Carbohydrate Metabolic Process Cellular Protein Modification Process Protein Glycosylation Protein Targeting To Lysosome Lysosome Organization Secretion Of Lysosomal Enzymes	Positive Regulation Of Receptor Recycling Golgi To Endosome Transport Endocytosis Vesicle Organization Endosomal Transport Receptor-mediated Endocytosis Of Virus By Host Cell Endocytic Recycling Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Population Proliferation Viral Entry Into Host Cell Clathrin Coat Assembly Membrane Organization Postsynaptic Neurotransmitter Receptor Internalization
Pathways			EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell
Drugs		N-Acetylglucosamine
Diseases
GWAS		Blood protein levels ( 30072576 29875488)	Blood urea nitrogen levels ( 31152163) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) IgE grass sensitization ( 22036096) PR interval ( 30046033 32439900)
Interacting Genes		7 interacting genes: AP2A1 BDKRB1 CCR8 DEGS1 EPS15 FURIN ZHX2	49 interacting genes: AGFG1 AGFG2 AP1G1 AP2A1 AP2A2 CLINT1 CORO7 CRK DNM1 DNM2 EGFR ELF3 EPN1 EPN2 FCHO1 FCHO2 GRB2 HGS ITSN1 LAPTM5 MAPK14 MOB4 MTNR1A NAGPA NEDD4 NUMB NUMBL PRKN REPS2 RNF11 SCAMP1 SGIP1 SNAP91 SPART SPOPL STAM2 STAMBP STON2 SYNJ1 TFAP2A UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H UBQLN1 USP8
Entrez ID		51172	2060
HPRD ID		12145	08968
Ensembl ID		ENSG00000103174	ENSG00000085832
Uniprot IDs		Q9UK23	B7Z240 P42566
PDB IDs			1C07 1EH2 1F8H 1FF1 2IV9 2JXC 4RH5 4RH9 4RHG 4S0G 5AWT 5AWU 5JP2
Enriched GO Terms of Interacting Partners?
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