PEX14 and MARF1

Data Source:
BioGRID (two hybrid)

		PEX14	MARF1
Description		peroxisomal biogenesis factor 14	meiosis regulator and mRNA stability factor 1
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Peroxisome Peroxisomal Membrane Membrane Integral Component Of Membrane Protein-containing Complex Peroxisomal Importomer Complex	Cytoplasm Peroxisome Golgi Apparatus Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Transcription Corepressor Activity Signaling Receptor Binding Protein Binding Microtubule Binding Identical Protein Binding Protein N-terminus Binding Beta-tubulin Binding	Molecular_function Protein Binding MRNA Binding Involved In Posttranscriptional Gene Silencing CCR4-NOT Complex Binding
	Biological Process	Protein Targeting To Peroxisome Peroxisome Organization Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Docking Protein Import Into Peroxisome Matrix, Translocation Protein Ubiquitination Negative Regulation Of Protein Binding Microtubule Anchoring Peroxisome Transport Along Microtubule Negative Regulation Of DNA-binding Transcription Factor Activity Protein Import Into Peroxisome Matrix, Substrate Release Negative Regulation Of Transcription, DNA-templated Protein-containing Complex Assembly	Double-strand Break Repair Female Meiotic Nuclear Division Regulation Of Gene Expression Negative Regulation Of Phosphatase Activity Posttranscriptional Gene Silencing Oogenesis
Pathways		E3 ubiquitin ligases ubiquitinate target proteins Peroxisomal protein import Peroxisomal protein import Class I peroxisomal membrane protein import
Drugs
Diseases		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		Asthma ( 27182965 32296059) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 29059683 23535729 23535733 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Breast size ( 27182965) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Facial morphology ( 31763980) Hand grip strength ( 29313844) Heel bone mineral density ( 30598549) LDL cholesterol ( 30275531) Male-pattern baldness ( 28196072) Metabolite levels ( 23823483) Optic nerve measurement (rim area) ( 20395239) Prostate cancer ( 25217961) Refractive error ( 32231278) Self-reported allergy ( 23817569) Total cholesterol levels ( 30275531)
Interacting Genes		14 interacting genes: CENPK COPS4 GET3 HDAC1 MARF1 MED8 MTNR1A NFE2 PEX19 PEX26 PEX5 PEX7 SMARCC2 ZHX1	7 interacting genes: GSC2 INCA1 MTNR1B PEX14 TCF4 UBE3A WDR5
Entrez ID		5195	9665
HPRD ID		03477	13992
Ensembl ID		ENSG00000142655	ENSG00000166783
Uniprot IDs		O75381	Q9Y4F3
PDB IDs		2W84 2W85 4BXU	2DGX 2DIU 6FDL
Enriched GO Terms of Interacting Partners?
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