IL1RN and IL1R2

Data Source:
HPRD (in vivo)

		IL1RN	IL1R2
Description		interleukin 1 receptor antagonist	interleukin 1 receptor type 2
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GO Annotations	Cellular Component	Extracellular Space Cytoplasm Plasma Membrane Extracellular Exosome	Extracellular Region Cytoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Cytokine Activity Interleukin-1, Type I Receptor Binding Interleukin-1, Type II Receptor Binding Interleukin-1 Receptor Antagonist Activity Protein Binding Interleukin-1 Type I Receptor Antagonist Activity Interleukin-1 Type II Receptor Antagonist Activity	Interleukin-1 Receptor Activity Interleukin-1, Type II, Blocking Receptor Activity Protein Binding Interleukin-1 Binding
	Biological Process	Inflammatory Response To Antigenic Stimulus Lipid Metabolic Process Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway Insulin Secretion Negative Regulation Of Heterotypic Cell-cell Adhesion Response To Glucocorticoid Interleukin-1-mediated Signaling Pathway Negative Regulation Of Interleukin-1-mediated Signaling Pathway	Immune Response Negative Regulation Of Protein Processing Cytokine-mediated Signaling Pathway Negative Regulation Of Interleukin-1 Alpha Production Interleukin-1-mediated Signaling Pathway Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways		Interleukin-10 signaling Interleukin-1 signaling	Interleukin-10 signaling Interleukin-1 signaling
Drugs		Rilonacept
Diseases		Graft-versus-host disease
GWAS		Blood protein levels ( 30072576 29875488) C-reactive protein ( 22939635) Dysmenorrheic pain ( 27454463) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) Granulocyte count ( 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Obesity-related traits ( 23251661) Protein quantitative trait loci ( 18464913) Red cell distribution width ( 32888494) Stroke ( 26089329) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252)	Ankylosing spondylitis ( 23749187 20062062) Asthma ( 31619474) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood protein levels ( 30072576 29875488) C-reactive protein levels ( 30388399) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) Inflammatory bowel disease ( 28067908 23128233) Parkinson's disease ( 32201043 28892059) Ulcerative colitis ( 21297633)
Interacting Genes		6 interacting genes: COPS3 COPS4 IL1R1 IL1R2 POT1 TERF2IP	5 interacting genes: IL1A IL1B IL1RAP IL1RN USP15
Entrez ID		3557	7850
HPRD ID		00978	00995
Ensembl ID		ENSG00000136689	ENSG00000115590
Uniprot IDs		A0A024R528 P18510	P27930
PDB IDs		1ILR 1ILT 1IRA 1IRP 1ITN 2IRT	3O4O
Enriched GO Terms of Interacting Partners?
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