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DERL2 and DIABLO
Data Source:
BioGRID
(two hybrid)
DERL2
DIABLO
Description
derlin 2
diablo IAP-binding mitochondrial protein
Image
No pdb structure
GO Annotations
Cellular Component
Hrd1p Ubiquitin Ligase ERAD-L Complex
Early Endosome
Late Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Membrane
Integral Component Of Endoplasmic Reticulum Membrane
Endoplasmic Reticulum Quality Control Compartment
Mitochondrion
Mitochondrial Intermembrane Space
Cytosol
Cytoplasmic Side Of Plasma Membrane
CD40 Receptor Complex
Molecular Function
Signal Recognition Particle Binding
Protein Binding
Protein-containing Complex Binding
Misfolded Protein Binding
Ubiquitin-specific Protease Binding
Protein Binding
Biological Process
Suckling Behavior
Positive Regulation Of Cell Population Proliferation
Viral Process
Positive Regulation Of Cell Growth
Ubiquitin-dependent ERAD Pathway
Endoplasmic Reticulum Unfolded Protein Response
Retrograde Protein Transport, ER To Cytosol
Negative Regulation Of Retrograde Protein Transport, ER To Cytosol
Endoplasmic Reticulum Mannose Trimming
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C
Positive Regulation Of Apoptotic Process
Neuron Apoptotic Process
Intrinsic Apoptotic Signaling Pathway
Pathways
ABC-family proteins mediated transport
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Defective CFTR causes cystic fibrosis
ER Quality Control Compartment (ERQC)
Release of apoptotic factors from the mitochondria
SMAC (DIABLO) binds to IAPs
SMAC (DIABLO) binds to IAPs
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
SMAC, XIAP-regulated apoptotic response
Regulation of the apoptosome activity
Drugs
Phenethyl Isothiocyanate
Diseases
GWAS
Asparaginase hypersensitivity in acute lymphoblastic leukemia (
25987655
)
Interacting Genes
12 interacting genes:
DIABLO
FXYD6
KRTAP10-3
KRTAP10-7
KRTAP10-8
LMNA
MELTF
MPP1
PTPN9
RBFA
SERPINA1
SFT2D1
42 interacting genes:
AGTRAP
APOC2
APOC4
AREL1
ARL6IP1
ARNT
BEX3
BIRC2
BIRC3
BIRC5
BIRC6
BIRC7
CASP9
CMTM4
DERL2
DGAT2L6
DHRS1
E2F1
EEF1A1
FADS6
FKBP7
HSD17B13
HTRA2
LTBR
MAML2
MICOS13
MPC2
NR4A1
RHBDD2
RMDN2
SEC22A
SFT2D1
SLC17A9
SLC25A47
SLC66A2
STMN4
SYP
TIMMDC1
UBE2K
UFM1
XIAP
ZNF746
Entrez ID
51009
56616
HPRD ID
16796
05560
Ensembl ID
ENSG00000072849
ENSG00000184047
Uniprot IDs
I3L3R8
Q9GZP9
A0A024RBT2
A0A0S2Z5P6
A0A0S2Z5U7
K7X1S0
Q502X2
Q9NR28
PDB IDs
1FEW
1G3F
1G73
1OXQ
1TW6
1XB0
1XB1
3D9U
3UIH
3UIJ
4TX5
6JX6
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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