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DIABLO and BIRC5
Data Source:
HPRD
(in vivo, in vitro)
DIABLO
BIRC5
Description
diablo IAP-binding mitochondrial protein
baculoviral IAP repeat containing 5
Image
GO Annotations
Cellular Component
Mitochondrion
Mitochondrial Intermembrane Space
Cytosol
Cytoplasmic Side Of Plasma Membrane
CD40 Receptor Complex
Nuclear Chromosome
Chromosome, Centromeric Region
Condensed Chromosome Kinetochore
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Spindle Microtubule
Midbody
Chromosome Passenger Complex
Molecular Function
Protein Binding
Protein Binding
Microtubule Binding
Enzyme Binding
Small GTPase Binding
Identical Protein Binding
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Metal Ion Binding
Chaperone Binding
Biological Process
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C
Positive Regulation Of Apoptotic Process
Neuron Apoptotic Process
Intrinsic Apoptotic Signaling Pathway
Protein Phosphorylation
Apoptotic Process
Chromosome Segregation
Sensory Perception Of Sound
Positive Regulation Of Cell Population Proliferation
Cytokine-mediated Signaling Pathway
Protein-containing Complex Localization
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Transcription, DNA-templated
Cell Division
Regulation Of Cell Cycle
Pathways
Release of apoptotic factors from the mitochondria
SMAC (DIABLO) binds to IAPs
SMAC (DIABLO) binds to IAPs
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
SMAC, XIAP-regulated apoptotic response
Regulation of the apoptosome activity
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
SUMOylation of DNA replication proteins
RHO GTPases Activate Formins
Interleukin-4 and Interleukin-13 signaling
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
Mitotic Prometaphase
Neddylation
EML4 and NUDC in mitotic spindle formation
Drugs
Phenethyl Isothiocyanate
Reserpine
Berberine
LY2181308
Diseases
GWAS
Blood trace element (Se levels) (
23720494
)
Periodontitis (Mean PAL) (
24024966
)
Interacting Genes
42 interacting genes:
AGTRAP
APOC2
APOC4
AREL1
ARL6IP1
ARNT
BEX3
BIRC2
BIRC3
BIRC5
BIRC6
BIRC7
CASP9
CMTM4
DERL2
DGAT2L6
DHRS1
E2F1
EEF1A1
FADS6
FKBP7
HSD17B13
HTRA2
LTBR
MAML2
MICOS13
MPC2
NR4A1
RHBDD2
RMDN2
SEC22A
SFT2D1
SLC17A9
SLC25A47
SLC66A2
STMN4
SYP
TIMMDC1
UBE2K
UFM1
XIAP
ZNF746
25 interacting genes:
AURKA
AURKB
AURKC
BIRC2
BIRC3
BIRC6
CASP3
CASP7
CASP9
CCDC85B
CDCA8
CDK1
CDK4
DIABLO
EVI5
FBXL7
H3-4
H3C14
HSP90AA1
INCENP
KCNJ6
RAN
RASA1
XIAP
XPO1
Entrez ID
56616
332
HPRD ID
05560
04520
Ensembl ID
ENSG00000184047
ENSG00000089685
Uniprot IDs
A0A024RBT2
A0A0S2Z5P6
A0A0S2Z5U7
K7X1S0
Q502X2
Q9NR28
A0A0B4J1S3
H3BLT4
O15392
PDB IDs
1FEW
1G3F
1G73
1OXQ
1TW6
1XB0
1XB1
3D9U
3UIH
3UIJ
4TX5
6JX6
1E31
1F3H
1XOX
2QFA
2RAW
2RAX
3UEC
3UED
3UEE
3UEF
3UEG
3UEH
3UEI
3UIG
3UIH
3UII
3UIJ
3UIK
4A0I
4A0J
4A0N
6SHO
6YIE
6YIF
6YIH
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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