AATF and PAWR

Data Source:
HPRD (in vivo)

		AATF	PAWR
Description		apoptosis antagonizing transcription factor	pro-apoptotic WT1 regulator
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm Golgi Apparatus	Chromatin Nucleus Cytoplasm Actin Filament Plasma Membrane Actin Cytoskeleton
	Molecular Function	RNA Binding Protein Binding Protein Kinase Binding Leucine Zipper Domain Binding Tau Protein Binding	Transcription Corepressor Activity Actin Binding Protein Binding Enzyme Binding Leucine Zipper Domain Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Cell Adhesion Regulation Of Mitotic Cell Cycle Negative Regulation Of Superoxide Anion Generation Embryonic Cleavage Ribosome Biogenesis Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Positive Regulation Of Gene Expression Negative Regulation Of B Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Fibroblast Proliferation Negative Regulation Of T Cell Receptor Signaling Pathway Actin Filament Bundle Assembly Apoptotic Signaling Pathway Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Cellular Senescence
Pathways		NRAGE signals death through JNK
Drugs
Diseases
GWAS		Body mass index ( 26426971) Erectile dysfunction ( 30583798) Obesity-related traits ( 23251661) Thyroid volume in Hashimotoâ€™s thyroiditis ( 32019955)	Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Brain morphology (MOSTest) ( 32665545)
Interacting Genes		28 interacting genes: ATM ATR AURKA CHEK1 CHEK2 CPD DAPK3 DAZAP2 EFNB3 FBXO7 HIPK2 LDOC1 LZTR1 MAPT MPHOSPH6 NEDD4L NGDN PALS2 PAWR PCBD2 POLR2J RB1 RELA SMAD3 SP1 SS18L1 TSG101 ZNF468	16 interacting genes: AATF ATP5F1C DAPK3 DRD2 HSPA5 PML PRKCZ RRAS2 SLC5A7 SPSB1 SPSB2 SPSB4 SQSTM1 TFPT THAP1 WT1
Entrez ID		26574	5074
HPRD ID		12236	09051
Ensembl ID		ENSG00000275700	ENSG00000177425
Uniprot IDs		Q9NY61	Q96IZ0
PDB IDs		5W6A	2JK9
Enriched GO Terms of Interacting Partners?
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