P4HB and NTM

Data Source:
BioGRID (two hybrid)

		P4HB	NTM
Description		prolyl 4-hydroxylase subunit beta	neurotrimin
Image
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Cytoskeleton Focal Adhesion External Side Of Plasma Membrane Procollagen-proline 4-dioxygenase Complex Lamellipodium Protein-containing Complex Melanosome Extracellular Exosome	Extracellular Region Plasma Membrane Anchored Component Of Membrane
	Molecular Function	RNA Binding Protein Disulfide Isomerase Activity Actin Binding Procollagen-proline 4-dioxygenase Activity Integrin Binding Protein Binding Peptide Disulfide Oxidoreductase Activity Thiol Oxidase Activity Protein Heterodimerization Activity	Protein Binding
	Biological Process	Protein Folding Protein Phosphopantetheinylation Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Chylomicron Assembly Very-low-density Lipoprotein Particle Assembly Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Interleukin-12-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Cell Adhesion Positive Regulation Of Viral Entry Into Host Cell Cellular Response To Hypoxia Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway	Cell Adhesion Neuron Recognition
Pathways		Collagen biosynthesis and modifying enzymes Detoxification of Reactive Oxygen Species Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Hedgehog ligand biogenesis VLDL assembly Post-translational protein phosphorylation Chylomicron assembly Interleukin-12 signaling Interleukin-23 signaling	Post-translational modification: synthesis of GPI-anchored proteins
Drugs		Zinc Ribostamycin Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS			Adult body size ( 32376654) Aggressiveness in attention deficit hyperactivity disorder ( 27021288) Asperger disorder ( 21182207) Blood protein levels ( 30072576) Body size at age 10 ( 32376654) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Familial lung adenocarcinoma ( 29924316) Feeling worry ( 29500382) Food addiction ( 27106561) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Glucocorticoid-induced osteonecrosis (time dependent analysis) ( 26265699) Gut microbiota (functional units) ( 27694959) Intake of total sugars ( 31005972) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Male fertility ( 22633400) Mental health study participation (completed survey) ( 31263887) Myopia ( 27182965) Obesity-related traits ( 23251661) Plasma anti-thyroglobulin levels ( 29678681) Pre-treatment viral load in HIV-1 infection ( 31219150) Refractive error ( 32231278) Serum polyunsaturated fatty acid concentration x sex interaction in metabolic syndrome ( 31991592) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Sunburns ( 23548203)
Interacting Genes		49 interacting genes: CD1D CHCHD2 CNNM3 COL10A1 COL1A1 COL1A2 CSNK2A2 CST2 EIF2S1 ENO1 ERO1A ERO1B ESR1 FAM71C FEZ1 FZD10 GRN HNRNPD ITGB3 KLHL42 KRTAP12-3 KRTAP13-2 KRTAP4-11 KRTAP5-9 KRTAP6-3 KRTAP9-8 LCE1B LCE2D LCE4A LCN2 LGALS9 LINC00839 LRFN4 NECTIN2 NOL4 NTM ODF1 P4HA2 P4HA3 PLCXD3 PRNP PTN SUMO2 TG TGFB1 UBQLN1 VWF YWHAG ZNF69	20 interacting genes: APP C19orf47 CCKBR EFEMP2 KRTAP1-1 KRTAP3-2 KRTAP5-9 KRTAP9-3 LHB LINGO1 LSAMP MRPL12 NBPF19 NEGR1 NOTCH2NLA P4HB PAX4 QRFPR SPRY1 VWC2
Entrez ID		5034	50863
HPRD ID		07181	06398
Ensembl ID		ENSG00000185624	ENSG00000182667
Uniprot IDs		A0A024R8S5 P07237	B7Z1I4 Q9P121
PDB IDs		1BJX 1MEK 1X5C 2BJX 2K18 3BJ5 3UEM 4EKZ 4EL1 4JU5 6I7S	6DLF
Enriched GO Terms of Interacting Partners?
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