ALDH7A1 and EPS8

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		ALDH7A1	EPS8
Description		aldehyde dehydrogenase 7 family member A1	epidermal growth factor receptor pathway substrate 8
Image
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Matrix Cytosol Extracellular Exosome	Plasma Membrane Cell Cortex Growth Cone Vesicle Stereocilium Ruffle Membrane Synapse Extracellular Exosome
	Molecular Function	Aldehyde Dehydrogenase (NAD+) Activity L-aminoadipate-semialdehyde Dehydrogenase Activity Protein Binding Betaine-aldehyde Dehydrogenase Activity Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (non-phosphorylating) Activity	Actin Binding Protein Binding Small GTPase Binding Signaling Adaptor Activity
	Biological Process	Cellular Aldehyde Metabolic Process Lysine Catabolic Process Sensory Perception Of Sound Glycine Betaine Biosynthetic Process From Choline Choline Catabolic Process	Rho Protein Signal Transduction Regulation Of Cell Shape Exit From Mitosis Rac Protein Signal Transduction Regulation Of Actin Filament Length Regulation Of Rho Protein Signal Transduction Dendritic Cell Migration Regulation Of Catalytic Activity Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Actin Crosslink Formation Actin Polymerization-dependent Cell Motility Positive Regulation Of Ruffle Assembly
Pathways		Choline catabolism Lysine catabolism
Drugs		NADH Artenimol
Diseases
GWAS		Colorectal cancer ( 30529582) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Metabolite levels ( 23823483) Osteoporosis ( 20072603)	Metabolite levels ( 23823483) Protein quantitative trait loci ( 18464913)
Interacting Genes		5 interacting genes: APP EPS8 LCN2 MYG1 RECQL5	61 interacting genes: ABI1 ACTA1 ADAM22 AIMP2 ALDH7A1 ARMC1 BAIAP2 BCKDK BLOC1S6 BORCS6 BYSL C19orf25 C6orf141 C8orf33 CASK CBL CCDC85B CSNK2B CTNNA3 CXCL2 DNALI1 DVL1 EGFR GOLGA8EP GRB2 GULP1 HNRNPC HOOK2 INPP5J ITGB1 ITGB3 ITGB5 ITSN2 MAP1LC3B MAP3K11 MRPL20 MYO15A NACC2 NFKB2 PCM1 PROSER2 RCAN3 RFXAP RSPH14 RUNX1T1 SCRN3 SERPINA5 SF3B3 SHB SHC1 SLC27A4 SMARCE1 SOS1 SRC TDP2 TEX28 TPRN USP6NL XAGE2 XRCC6 ZZZ3
Entrez ID		501	2059
HPRD ID		00124	02563
Ensembl ID		ENSG00000164904	ENSG00000151491
Uniprot IDs		P49419	B4E3T6 Q12929
PDB IDs		2J6L 4X0T 4X0U 4ZUK 4ZUL 4ZVW 4ZVX 4ZVY 6O4B 6O4C 6O4D 6O4E 6O4F 6O4G 6O4H 6O4I 6O4K 6O4L 6U2X	2E8M
Enriched GO Terms of Interacting Partners?
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