VAMP4 and KASH5

Data Source:
BioGRID (two hybrid)

		VAMP4	KASH5
Description		vesicle associated membrane protein 4	KASH domain containing 5
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosome Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Synaptic Vesicle Cell Surface Transport Vesicle Integral Component Of Synaptic Vesicle Membrane Clathrin-coated Vesicle Membrane SNARE Complex Trans-Golgi Network Membrane	Chromosome, Telomeric Region Lateral Element Nuclear Outer Membrane Integral Component Of Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Meiotic Spindle Pole
	Molecular Function	Protein Binding	Protein Binding Identical Protein Binding Dynein Complex Binding
	Biological Process	Microtubule Cytoskeleton Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Synaptic Vesicle To Endosome Fusion SNARE Complex Assembly Golgi To Plasma Membrane Protein Transport Membrane Organization Golgi Ribbon Formation Regulation Of Synaptic Vesicle Endocytosis	Double-strand Break Repair Via Homologous Recombination Actin Filament Organization Homologous Chromosome Pairing At Meiosis Spermatogenesis Telomere Localization Oogenesis Spindle Assembly Spindle Localization Microtubule Cytoskeleton Organization Involved In Homologous Chromosome Segregation Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation
Pathways		Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Hippocampal atrophy ( 25625606) Metabolite levels ( 23823483) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		45 interacting genes: ANKS6 AP1M1 AQP6 ARL13B BCL2L13 CISD2 CPLX4 CSNK2A1 CYB5R3 DNAJC5 EBP ELOVL4 ERGIC3 EVI2B FAM209A FAM210B GPR152 GPX8 KASH5 LDLRAD1 LEUTX MFF MGST3 MTIF3 PACS1 PSCA PTGES REEP4 RETREG3 SAR1A SEC11C SLC10A6 SNAP29 SSMEM1 STOM STX16 STX1A STX4 STX6 SYT2 TM4SF19 TMEM205 TMEM51 TMX2 TRIM54	112 interacting genes: ABHD1 ADIPOQ ANKRD46 ATF7 BAG5 BCL2L2 BET1 C14orf180 CCDC120 CCDC87 CDC73 CDKL3 CIB3 CLDN8 CMTM5 CRABP2 CTXN3 CWF19L2 CXCL16 CXCL9 CYBC1 DERL1 DNAJC30 EFNA5 EMD FAM161A FAM241B FAM50B FAM90A1 FATE1 FIS1 FRA10AC1 FTCD FXYD3 GABARAPL2 GALNT2 GIMAP5 GOSR2 GPATCH4 GPR25 HMOX1 ITGAM ITM2B JAGN1 KDM1A LARP1 LAT LENG1 LHFPL5 LMNA LRCH4 MALL MARCHF2 MFSD5 MMP14 MOSPD3 MS4A1 MTX2 NRIP3 NSG1 NTAQ1 OLFM4 PDGFRA PGAP2 PGRMC1 PIGU PLP2 PLPP6 PPP1R18 RIPPLY2 RNF146 RSPH14 RSRC2 RTP2 SENP2 SERP2 SGTA SHMT2 SLC30A2 SLC35B4 SLC41A1 SLC41A2 SLC5A4 SLN SMCO4 SNAP47 STBD1 STX12 STX5 TCF25 TMEM11 TMEM147 TMEM14C TMEM19 TMEM199 TMEM41A TMEM86A TMPRSS4 TNF TRAF3IP3 TRARG1 TSHZ3 TTC23 UPK1B UPK2 VAMP1 VAMP2 VAMP4 VTI1B ZC2HC1C ZFPL1 ZNF250
Entrez ID		8674	147872
HPRD ID		06070	08134
Ensembl ID		ENSG00000117533	ENSG00000161609
Uniprot IDs		O75379 Q6IAZ3	Q8N6L0
PDB IDs			6R2I
Enriched GO Terms of Interacting Partners?
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