OCLN and FATE1

Data Source:
BioGRID (two hybrid)

		OCLN	FATE1
Description		occludin	fetal and adult testis expressed 1
Image			No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Plasma Membrane Cell-cell Junction Bicellular Tight Junction Integral Component Of Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Lateral Plasma Membrane Cell Junction Endocytic Vesicle Cell Leading Edge Cytoplasmic Vesicle Protein-containing Complex Tight Junction	Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Mitochondria-associated Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding Protein Domain Specific Binding	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Glucose Transmembrane Transport Positive Regulation Of Microtubule Polymerization Maintenance Of Blood-brain Barrier Cell-cell Junction Organization Positive Regulation Of Glucose Import Protein-containing Complex Assembly Response To Interleukin-18 Bicellular Tight Junction Assembly Cellular Response To Tumor Necrosis Factor Positive Regulation Of Wound Healing Protein Localization To Cell Leading Edge Positive Regulation Of Blood-brain Barrier Permeability Regulation Of Bicellular Tight Junction Assembly	Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Mitochondrial Calcium Ion Concentration
Pathways		Apoptotic cleavage of cell adhesion proteins RUNX1 regulates expression of components of tight junctions
Drugs
Diseases		Band-like calcification with simplified gyration and polymicrogyria (BLC-PMG); Pseudo-TORCH syndrome
GWAS		Hand grip strength (Mahalanobis distance) ( 32235003) Interleukin-18 levels ( 27989323)	Systemising ( 31508503)
Interacting Genes		11 interacting genes: CLEC7A CSNK1A1 CSNK2A1 FATE1 GPX8 PTPN2 SNW1 SYNE4 TJP1 TNFAIP3 ULK1	99 interacting genes: AGTRAP APOL3 AQP9 ASGR2 ATCAY BCL2L2 BIK BNIP2 BNIP3 BNIP3L BSND BTN2A2 C1QL4 CALN1 CCDC70 CD302 CD79A CD83 CDC37 CERS4 CREB3L3 CSF2RA CTRL CXCR1 CXCR3 DCTN5 DNAJC30 EMD FAM177A1 FAM209A FRMD8 GIMAP5 GINM1 GOSR2 GPR25 HSD17B13 INPP5K KASH5 KCNS2 LMNA LNPEP LRRC25 MARCHF2 MARCHF3 MARCHF5 MARVELD2 MFF MOSPD3 MR1 NDUFB11 NRG4 NRSN1 OCLN OTOP2 PIN4 PKMYT1 PLP2 PRRG2 RBFA RIC3 RNF183 RPRM RTP2 SCAMP5 SEC22A SEC22C SEC23A SEC23B SLC38A1 SLC41A2 SLC7A1 SLC7A14 SMIM14 SNAP47 SSMEM1 SYNDIG1 SYNE4 SYNGR1 SYNGR2 SYNPR TBP TIMMDC1 TM4SF4 TMEM11 TMEM179B TMEM201 TMEM74 TRAF2 TRAF3IP3 UBE2I UNC93B1 USHBP1 USP20 VSIG4 VSTM1 YIPF2 YIPF4 ZCCHC12 ZFPL1
Entrez ID		100506658	89885
HPRD ID			02346
Ensembl ID		ENSG00000197822	ENSG00000147378
Uniprot IDs		A8K3T2 Q16625	Q969F0
PDB IDs		1WPA 1XAW 3G7C
Enriched GO Terms of Interacting Partners?
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