NTRK3 and KPNA4

Data Source:
BioGRID (two hybrid)

		NTRK3	KPNA4
Description		neurotrophic receptor tyrosine kinase 3	karyopherin subunit alpha 4
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Axon Receptor Complex	Nucleus Nucleoplasm Cytosol Nuclear Membrane
	Molecular Function	P53 Binding Transmembrane Receptor Protein Tyrosine Kinase Activity Neurotrophin Receptor Activity Protein Binding ATP Binding Neurotrophin Binding	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	Activation Of MAPK Activity Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Nervous System Development Heart Development Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Phospholipase C Activity Positive Regulation Of Neuron Projection Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Cell Differentiation Positive Regulation Of Cell Migration Activation Of Protein Kinase B Activity Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Kinase Activity Neurotrophin Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Positive Chemotaxis Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Protein Kinase B Signaling Positive Regulation Of ERK1 And ERK2 Cascade Activation Of GTPase Activity Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Actin Cytoskeleton Reorganization	NLS-bearing Protein Import Into Nucleus Modulation By Virus Of Host Cellular Process
Pathways		Receptor-type tyrosine-protein phosphatases NTF3 activates NTRK3 signaling NTF3 activates NTRK3 signaling Signaling by NTRK3 (TRKC) Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through RAS Activated NTRK3 signals through PI3K Activated NTRK3 signals through PI3K NTRK3 as a dependence receptor	ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways
Drugs		Entrectinib Fostamatinib Larotrectinib Pralsetinib
Diseases		Neuroblastoma
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood protein levels ( 30072576) Diabetic peripheral neuropathy in type 2 diabetes ( 31127053) Gaucher disease severity ( 22388998) General risk tolerance (MTAG) ( 30643258)	Alcohol use disorder (total score) ( 30336701) Attention deficit hyperactivity disorder ( 32279069) Bipolar disorder ( 31043756) Malaria ( 31844061) Myeloproliferative neoplasms ( 33057200) Pit-and-Fissure caries ( 24556642) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Smooth-surface caries ( 24556642) Total cholesterol levels ( 30275531)
Interacting Genes		28 interacting genes: APP BEX3 DOK5 DOK6 DYNLL1 ERBB2 FRS2 HEY1 HTR2A IRAK1 IRAK3 JUN KIDINS220 KPNA4 MAPK1 MAPK3 NELFB NGFR NSD1 NTF3 PLCG1 PTPN1 RASGRF1 SHC1 SHC2 SORT1 SQSTM1 WDR13	26 interacting genes: APP CDKN1B CSE1L CSNK2A1 CUL4B CYHR1 EXO1 FAM50B GTF2IRD1 HIF1A HNRNPC HSD3B7 KAT5 KPNB1 MAT2B MTA1 NCBP3 NTRK3 NUP50 PLAA RAC1 RCC1 RECQL TGM2 TP53 WT1
Entrez ID		4916	3840
HPRD ID		01870	04275
Ensembl ID		ENSG00000140538	ENSG00000186432
Uniprot IDs		B7Z7U4 O95193 Q16288 Q96CY4 X5D2R1 X5D7M5 X5DNW6	O00629
PDB IDs		1WWC 3V5Q 4YMJ 6KZC 6KZD	4UAE 5TBK 5XZX 6BVV 6BVZ 6BW9 6BWA 6BWB 6WX8 7JJL
Enriched GO Terms of Interacting Partners?
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