KPNA4 and RCC1

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		KPNA4	RCC1
Description		karyopherin subunit alpha 4	regulator of chromosome condensation 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Membrane	Chromatin Condensed Nuclear Chromosome Nucleus Nucleoplasm Cytoplasm Nuclear Membrane Protein-containing Complex
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity	Chromatin Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding Nucleosome Binding Nucleosomal DNA Binding Histone Binding Sulfate Binding Protein Heterodimerization Activity
	Biological Process	NLS-bearing Protein Import Into Nucleus Modulation By Virus Of Host Cellular Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Spindle Organization Chromosome Segregation Regulation Of Mitotic Nuclear Division Viral Process Ran Protein Signal Transduction Regulation Of Catalytic Activity Spindle Assembly Cell Division Regulation Of Mitotic Spindle Assembly
Pathways		ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways	Rev-mediated nuclear export of HIV RNA Nuclear import of Rev protein Postmitotic nuclear pore complex (NPC) reformation
Drugs
Diseases
GWAS		Alcohol use disorder (total score) ( 30336701) Attention deficit hyperactivity disorder ( 32279069) Bipolar disorder ( 31043756) Malaria ( 31844061) Myeloproliferative neoplasms ( 33057200) Pit-and-Fissure caries ( 24556642) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Smooth-surface caries ( 24556642) Total cholesterol levels ( 30275531)	Night sleep phenotypes ( 27126917) Systolic blood pressure ( 30578418)
Interacting Genes		26 interacting genes: APP CDKN1B CSE1L CSNK2A1 CUL4B CYHR1 EXO1 FAM50B GTF2IRD1 HIF1A HNRNPC HSD3B7 KAT5 KPNB1 MAT2B MTA1 NCBP3 NTRK3 NUP50 PLAA RAC1 RCC1 RECQL TGM2 TP53 WT1	50 interacting genes: ACTB APLP1 BAG6 CCT7 CDK1 CDK2AP2 CHGB CHKA CSAD CSNK1A1 DDAH2 DYNC1I1 ERCC6 FAF1 FBXO7 FLAD1 GNB2 H2AC18 H2AC20 H2BC21 H3C1 HADHB HMGA1 HOXD8 KMT2B KPNA3 KPNA4 LRIF1 NGFR NTMT1 NUDT21 NUP98 PDHB PKM PTMA RAN RANBP1 RANBP3 RPA1 SDF4 SPRED1 SUMO2 TLE1 TRMT2A TUBB3 UNC119 USP4 WIZ XPO1 ZNF135
Entrez ID		3840	1104
HPRD ID		04275	01559
Ensembl ID		ENSG00000186432	ENSG00000180198
Uniprot IDs		O00629	A0A0S2Z3I4 A0A0S2Z404 P18754 Q5T081
PDB IDs		4UAE 5TBK 5XZX 6BVV 6BVZ 6BW9 6BWA 6BWB 6WX8 7JJL	1A12 1I2M 5E1B 5E1D 5E1M 5E1O 5E2A 5E2B 5TBK 6DUB
Enriched GO Terms of Interacting Partners?
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