NRTN and GFRA2

Data Source:
BioGRID (pull down, pull down)
HPRD (in vivo)

		NRTN	GFRA2
Description		neurturin	GDNF family receptor alpha 2
Image
GO Annotations	Cellular Component	Extracellular Region Axon	Plasma Membrane External Side Of Plasma Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Receptor Complex
	Molecular Function	Signaling Receptor Binding Growth Factor Activity Glial Cell-derived Neurotrophic Factor Receptor Binding Receptor Tyrosine Kinase Binding	Glial Cell-derived Neurotrophic Factor Receptor Activity Signaling Receptor Activity
	Biological Process	MAPK Cascade Neural Crest Cell Migration Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Nerve Development Neuron Projection Development	MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Negative Regulation Of Protein Autophosphorylation Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway
Pathways		NCAM1 interactions RAF/MAP kinase cascade RET signaling	NCAM1 interactions RAF/MAP kinase cascade RET signaling
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Blood protein levels ( 29875488) Chronotype ( 30696823) N-glycan levels ( 21908519 21203500 31163085)	Blood protein levels ( 30072576 29875488 28240269) Diisocyanate-induced asthma ( 25918132) Frontotemporal dementia ( 29724592) Frontotemporal dementia with GRN mutation ( 29724592) Migraine with aura ( 23793025) Neuropathic pain in type 2 diabetes ( 24974787) Nicotine dependence symptom count ( 25555482) Pelvic organ prolapse (moderate/severe) ( 26545240) Response to lithium treatment in bipolar disorder ( 26806518) Trunk fat mass ( 28552196) Verbal declarative memory ( 25648963)
Interacting Genes		3 interacting genes: GFRA1 GFRA2 RET	2 interacting genes: GDNF NRTN
Entrez ID		4902	2675
HPRD ID		03604	11801
Ensembl ID		ENSG00000171119	ENSG00000168546
Uniprot IDs		Q99748	O00451
PDB IDs		5MR4 5MR5 5MR9 5NMZ 6GL7 6Q2O 6Q2R	5MR4 5MR5 6GL7 6Q2O 6Q2R
Enriched GO Terms of Interacting Partners?
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