GFRA2 and NRTN

Data Source:
BioGRID (pull down, pull down)
HPRD (in vivo)

		GFRA2	NRTN
Description		GDNF family receptor alpha 2	neurturin
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Receptor Complex	Extracellular Region Axon
	Molecular Function	Glial Cell-derived Neurotrophic Factor Receptor Activity Signaling Receptor Activity	Signaling Receptor Binding Growth Factor Activity Glial Cell-derived Neurotrophic Factor Receptor Binding Receptor Tyrosine Kinase Binding
	Biological Process	MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Negative Regulation Of Protein Autophosphorylation Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway	MAPK Cascade Neural Crest Cell Migration Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Nerve Development Neuron Projection Development
Pathways		NCAM1 interactions RAF/MAP kinase cascade RET signaling	NCAM1 interactions RAF/MAP kinase cascade RET signaling
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Diisocyanate-induced asthma ( 25918132) Frontotemporal dementia ( 29724592) Frontotemporal dementia with GRN mutation ( 29724592) Migraine with aura ( 23793025) Neuropathic pain in type 2 diabetes ( 24974787) Nicotine dependence symptom count ( 25555482) Pelvic organ prolapse (moderate/severe) ( 26545240) Response to lithium treatment in bipolar disorder ( 26806518) Trunk fat mass ( 28552196) Verbal declarative memory ( 25648963)	Advanced age-related macular degeneration ( 26691988) Blood protein levels ( 29875488) Chronotype ( 30696823) N-glycan levels ( 21908519 21203500 31163085)
Interacting Genes		2 interacting genes: GDNF NRTN	3 interacting genes: GFRA1 GFRA2 RET
Entrez ID		2675	4902
HPRD ID		11801	03604
Ensembl ID		ENSG00000168546	ENSG00000171119
Uniprot IDs		O00451	Q99748
PDB IDs		5MR4 5MR5 6GL7 6Q2O 6Q2R	5MR4 5MR5 5MR9 5NMZ 6GL7 6Q2O 6Q2R
Enriched GO Terms of Interacting Partners?
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