NFIA and NFIB

Data Source:
BioGRID (two hybrid)

		NFIA	NFIB
Description		nuclear factor I A	nuclear factor I B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cell Junction	Chromatin Fibrillar Center Nucleus Nucleoplasm Cerebellar Mossy Fiber
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA Replication Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Viral Genome Replication Positive Regulation Of Transcription By RNA Polymerase II Synapse Maturation Ureter Development	Chondrocyte Differentiation DNA Replication Regulation Of Transcription By RNA Polymerase II Brain Development Glial Cell Differentiation Principal Sensory Nucleus Of Trigeminal Nerve Development Anterior Commissure Morphogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Club Cell Differentiation Type I Pneumocyte Differentiation Type II Pneumocyte Differentiation Lung Ciliated Cell Differentiation Commissural Neuron Axon Guidance Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Negative Regulation Of Mesenchymal Cell Proliferation Involved In Lung Development Negative Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis
Pathways		RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation	RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation
Drugs
Diseases
GWAS		Bipolar disorder ( 21738484) Blond vs. brown/black hair color ( 30531825) Celiac disease ( 20190752 25920553 30572963) Cobalt levels ( 26025379) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic conduction measures ( 23463857) Electrocardiographic traits ( 32602732) Erectile dysfunction ( 30583798) Feeling nervous ( 29500382) General risk tolerance (MTAG) ( 30643258) Global electrical heterogeneity phenotypes ( 29622589) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 28552196) JT interval (sulfonylurea treatment interaction) ( 27958378) Myopia ( 27182965) Number of sexual partners ( 30643258) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) PR interval ( 32439900) QRS duration ( 30679814 27577874 27659466) QT interval (sulfonylurea treatment interaction) ( 27958378) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889) Risk-taking tendency (4-domain principal component model) ( 30643258) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997) Triglyceride levels ( 32203549)	Adult body size ( 32376654) Adverse response to drug ( 30420678) Alcoholic chronic pancreatitis ( 28754779) Alzheimer's disease biomarkers ( 23419831) Ankle injury ( 28957384) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778) Factor VIII levels ( 30586737) HDL cholesterol levels ( 32203549) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Metastasis at diagnosis in osteosarcoma ( 26084801) Red blood cell count ( 32888494)
Interacting Genes		9 interacting genes: CREBBP FBXO7 GABARAPL1 NFIB PLEKHF2 SMAD2 SMAD3 SMAD4 UBC	4 interacting genes: NFIA NFIC NFIX RFX1
Entrez ID		4774	4781
HPRD ID		09007	09008
Ensembl ID		ENSG00000162599	ENSG00000147862
Uniprot IDs		Q12857	A0A0A0MRX8 O00712 Q5VW26 Q5VW28
PDB IDs
Enriched GO Terms of Interacting Partners?
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