NCF2 and PRDX6

Data Source:
HPRD (in vivo)

		NCF2	PRDX6
Description		neutrophil cytosolic factor 2	peroxiredoxin 6
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GO Annotations	Cellular Component	Acrosomal Vesicle Cytosol Membrane Phagolysosome NADPH Oxidase Complex	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Cytosol Membrane Azurophil Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Protein C-terminus Binding Electron Transfer Activity Superoxide-generating NAD(P)H Oxidase Activity Superoxide-generating NADPH Oxidase Activator Activity	Glutathione Peroxidase Activity Phospholipase A2 Activity Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Cadherin Binding 1-acylglycerophosphocholine O-acyltransferase Activity Calcium-independent Phospholipase A2 Activity Peroxiredoxin Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)
	Biological Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Superoxide Metabolic Process Phagocytosis Cellular Defense Response Electron Transport Chain Cellular Response To Oxidative Stress Superoxide Anion Generation Innate Immune Response Cell Redox Homeostasis Respiratory Burst Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Catalytic Activity	Response To Oxidative Stress Cellular Response To Oxidative Stress Hydrogen Peroxide Catabolic Process Neutrophil Degranulation Cell Redox Homeostasis Glycerophospholipid Catabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Cellular Oxidant Detoxification
Pathways		ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases	Detoxification of Reactive Oxygen Species Neutrophil degranulation
Drugs		Dextromethorphan	2-(N-morpholino)ethanesulfonic acid Copper
Diseases		Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
GWAS		Celiac disease ( 31591516) Celiac disease and Rheumatoid arthritis ( 26546613) Systemic lupus erythematosus ( 27399966 26606652 26502338 28714469 19838195) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)	Adult body size ( 32376654) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Blood protein levels ( 30072576) Systemic lupus erythematosus ( 26663301) Systemic sclerosis ( 31672989)
Interacting Genes		15 interacting genes: AKT1 CDC42 CYBA CYBB GOLGA2 KIFAP3 NCF1 NCF4 PRDX6 PRKDC RAC1 RAC2 S100A8 S100A9 SYTL1	21 interacting genes: CASP10 CASP8 GPX4 GSTP1 HNF4G MAPK1 NCF2 NR4A1 ORM2 PAXIP1 PPARD PSMD8 RARA SFTPA1 STH SUMO2 SUMO4 TERF1 TERF2IP UCHL5 YWHAE
Entrez ID		4688	9588
HPRD ID		01991	03817
Ensembl ID		ENSG00000116701	ENSG00000117592
Uniprot IDs		A0A0S2Z457 P19878	P30041 V9HWC7
PDB IDs		1E96 1HH8 1K4U 1OEY 1WM5 2DMO	1PRX 5B6M 5B6N
Enriched GO Terms of Interacting Partners?
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