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NCF2
Description
neutrophil cytosolic factor 2
Image
GO Annotations
Cellular Component
Acrosomal Vesicle
Cytosol
Membrane
Phagolysosome
NADPH Oxidase Complex
Molecular Function
Protein Binding
Protein C-terminus Binding
Electron Transfer Activity
Superoxide-generating NAD(P)H Oxidase Activity
Superoxide-generating NADPH Oxidase Activator Activity
Biological Process
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Superoxide Metabolic Process
Phagocytosis
Cellular Defense Response
Electron Transport Chain
Cellular Response To Oxidative Stress
Superoxide Anion Generation
Innate Immune Response
Cell Redox Homeostasis
Respiratory Burst
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Catalytic Activity
Pathways
ROS and RNS production in phagocytes
Cross-presentation of particulate exogenous antigens (phagosomes)
Detoxification of Reactive Oxygen Species
VEGFA-VEGFR2 Pathway
RHO GTPases Activate NADPH Oxidases
Drugs
Dextromethorphan
Diseases
Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
GWAS
Celiac disease (
31591516
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Systemic lupus erythematosus (
27399966
26606652
26502338
28714469
19838195
)
Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) (
30573655
)
Interacting Genes
15 interacting genes:
AKT1
CDC42
CYBA
CYBB
GOLGA2
KIFAP3
NCF1
NCF4
PRDX6
PRKDC
RAC1
RAC2
S100A8
S100A9
SYTL1
Entrez ID
4688
HPRD ID
01991
Ensembl ID
ENSG00000116701
Uniprot IDs
A0A0S2Z457
P19878
PDB IDs
1E96
1HH8
1K4U
1OEY
1WM5
2DMO
Enriched GO Terms of Interacting Partners
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