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RHEB and TSC2
Data Source:
BioGRID
(affinity chromatography technology, pull down, affinity chromatography technology)
HPRD
(in vitro)
RHEB
TSC2
Description
Ras homolog, mTORC1 binding
TSC complex subunit 2
Image
No pdb structure
GO Annotations
Cellular Component
Golgi Membrane
Spliceosomal Complex
Lysosomal Membrane
Endoplasmic Reticulum Membrane
Cytosol
Plasma Membrane
Postsynaptic Density
Membrane
Extracellular Exosome
Nucleus
Cytoplasm
Lysosome
Golgi Apparatus
Cytosol
Postsynaptic Density
Membrane
TSC1-TSC2 Complex
Perinuclear Region Of Cytoplasm
Molecular Function
Magnesium Ion Binding
GTPase Activity
Protein Binding
GTP Binding
GDP Binding
Protein Kinase Binding
GTPase Activator Activity
Protein Binding
Phosphatase Binding
Small GTPase Binding
Protein Homodimerization Activity
Hsp90 Protein Binding
Biological Process
Cell Cycle Arrest
Signal Transduction
Small GTPase Mediated Signal Transduction
Regulation Of Macroautophagy
Positive Regulation Of TOR Signaling
Positive Regulation Of Oligodendrocyte Differentiation
Negative Regulation Of Cold-induced Thermogenesis
Regulation Of Type B Pancreatic Cell Development
Neural Tube Closure
Negative Regulation Of Protein Kinase Activity
Protein Import Into Nucleus
Endocytosis
Heart Development
Protein Localization
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Phosphatidylinositol 3-kinase Signaling
Viral Process
Vesicle-mediated Transport
Positive Regulation Of Macroautophagy
Regulation Of Endocytosis
Negative Regulation Of Wnt Signaling Pathway
Negative Regulation Of TOR Signaling
Anoikis
Protein Kinase B Signaling
Positive Regulation Of GTPase Activity
Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Insulin Receptor Signaling Pathway
Insulin-like Growth Factor Receptor Signaling Pathway
Positive Chemotaxis
Regulation Of Small GTPase Mediated Signal Transduction
Regulation Of Cell Cycle
Negative Regulation Of Protein Kinase B Signaling
Negative Regulation Of Mitophagy
Pathways
Macroautophagy
MTOR signalling
mTORC1-mediated signalling
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of PTEN gene transcription
Amino acids regulate mTORC1
Macroautophagy
Inhibition of TSC complex formation by PKB
AKT phosphorylates targets in the cytosol
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in Cancer
TBC/RABGAPs
Drugs
Guanosine-5'-Triphosphate
Guanosine-5'-Diphosphate
Diseases
Lymphangioleiomyomatosis (LAM)
Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS
Carboplatin disposition in epthelial ovarian cancer (
29367611
)
Metabolite levels (
23823483
)
Major depressive disorder (
29317602
)
Obesity-related traits (
23251661
)
White blood cell count (
32888494
)
Interacting Genes
29 interacting genes:
A2M
APOE
APPBP2
ARIH2
ATM
ATR
BNIP3
BNIP3L
BRAF
CREB3
ECSIT
FKBP8
HTT
MTOR
NCAM1
PDE6D
PLD1
PSEN1
PSEN2
RABAC1
RAF1
RNF152
RPS6KB1
RPTOR
TRIM55
TRIM63
TSC1
TSC2
USP4
44 interacting genes:
AKT1
AKT2
AKT3
CALM1
CBY2
CCND1
CDKN1B
ESR1
FBXL6
FBXW5
GRB2
GSK3B
LNX1
MAPK1
MAPK3
MAPKAPK2
MDFI
NEK1
PAM
PIN1
PLK2
PPP2CA
PRKAA1
PTK2
PTPN11
RAB5A
RABEP1
RHEB
RPS6KA1
SFN
SMAD2
SMAD3
SUPT6H
TK1
TRIM55
TRIM63
TSC1
UBE3A
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
Entrez ID
6009
7249
HPRD ID
03188
01850
Ensembl ID
ENSG00000106615
ENSG00000103197
Uniprot IDs
A0A090N900
Q15382
B3KWH7
H3BMQ0
P49815
Q5HYF7
X5D7Q2
PDB IDs
1XTQ
1XTR
1XTS
3SEA
3T5G
5YXH
6BCU
6BSX
6BT0
7BTA
7BTC
7BTD
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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