CEACAM6 and CEACAM5

Data Source:
BioGRID (pull down)

		CEACAM6	CEACAM5
Description		CEA cell adhesion molecule 6	CEA cell adhesion molecule 5
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Cell Surface Apical Plasma Membrane Anchored Component Of Membrane Azurophil Granule Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Anchored Component Of Membrane Extracellular Exosome Integral Component Of External Side Of Plasma Membrane
	Molecular Function	Protein Binding Identical Protein Binding Protein Heterodimerization Activity	Protein Binding GPI Anchor Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Apoptotic Process Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Positive Regulation Of Heterotypic Cell-cell Adhesion Neutrophil Degranulation Leukocyte Migration Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin Negative Regulation Of Anoikis	Apoptotic Process Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Negative Regulation Of Myotube Differentiation Homotypic Cell-cell Adhesion Negative Regulation Of Apoptotic Process Leukocyte Migration Negative Regulation Of Anoikis
Pathways		Fibronectin matrix formation Cell surface interactions at the vascular wall Neutrophil degranulation	Post-translational modification: synthesis of GPI-anchored proteins Cell surface interactions at the vascular wall
Drugs			Labetuzumab S-[(1-Hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate
Diseases
GWAS		Serum carcinoembryonic antigen levels ( 31666285)	Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Serum carcinoembryonic antigen levels ( 31666285)
Interacting Genes		32 interacting genes: APP ASPG CARTPT CEACAM1 CEACAM5 CEACAM7 CEACAM8 CIB1 CSTF2 EXOC3L1 FOXH1 GCM2 GPANK1 HGS HPCAL4 KANK2 MSS51 MYOZ1 PITX1 POM121 QRICH1 RHOXF2 SHC3 SMARCD1 TLX3 TNXB UBQLN2 VENTX VEZF1 WWOX ZMYND19 ZNF76	6 interacting genes: CEACAM1 CEACAM6 DISP3 EWSR1 HNRNPM UQCC2
Entrez ID		4680	1048
HPRD ID		01233	00274
Ensembl ID		ENSG00000086548	ENSG00000105388
Uniprot IDs		P40199	A0A024R0K5 P06731 Q53G30
PDB IDs		4WHC 4WTZ 4Y8A 4YIQ	1E07 2QSQ 2QST 2VER
Enriched GO Terms of Interacting Partners?
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