MYO9B and ARFGEF1

Data Source:
HPRD (two hybrid, in vitro)

		MYO9B	ARFGEF1
Description		myosin IXB	ADP ribosylation factor guanine nucleotide exchange factor 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Actin Filament Cell Cortex Actin Cytoskeleton Membrane Myosin Complex Perinuclear Region Of Cytoplasm	Golgi Membrane Nucleoplasm Nucleolus Golgi Apparatus Trans-Golgi Network Cytosol Nuclear Matrix Small Nuclear Ribonucleoprotein Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Microfilament Motor Activity Actin Binding GTPase Activator Activity Protein Binding Calmodulin Binding ATP Binding ATPase Activity Small GTPase Binding Protein Homodimerization Activity ADP Binding Metal Ion Binding Roundabout Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Myosin Binding Protein Kinase A Regulatory Subunit Binding
	Biological Process	Rho Protein Signal Transduction Actin Filament-based Movement ARF Protein Signal Transduction Regulation Of Rho Protein Signal Transduction Roundabout Signaling Pathway Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	Exocytosis Golgi Organization Endomembrane System Organization Protein Transport Negative Regulation Of Actin Filament Polymerization Neuron Projection Development Regulation Of ARF Protein Signal Transduction Negative Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Protein Glycosylation In Golgi Positive Regulation Of Wound Healing Regulation Of Establishment Of Cell Polarity
Pathways		Rho GTPase cycle Regulation of actin dynamics for phagocytic cup formation SLIT2:ROBO1 increases RHOA activity FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Asthma ( 32296059) Coronary artery disease ( 29212778 33020668) Diastolic blood pressure ( 27841878) Glycated hemoglobin levels ( 24647736 28898252) Height ( 20881960 31562340 29782485) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 29403010 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Night sleep phenotypes ( 27126917) Platelet count ( 29403010 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Prostate cancer ( 29892016) Prostate cancer (early onset) ( 29892016) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Selective IgA deficiency ( 27723758) Systolic blood pressure ( 27841878 30578418) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Waist-to-hip ratio adjusted for BMI ( 28552196)	Chronic central serous retinopathy ( 30073298) Hearing function ( 25060954) Hip circumference adjusted for BMI ( 28552196)
Interacting Genes		6 interacting genes: ACTA1 ARFGEF1 CALM1 LRRC41 MOB4 PKN2	5 interacting genes: ARFGEF2 CTNNB1 DPY30 FKBP2 MYO9B
Entrez ID		4650	10565
HPRD ID		03677	09163
Ensembl ID		ENSG00000099331	ENSG00000066777
Uniprot IDs		B0I1T6 Q13459 Q4LE74 Q8WVD2	A0A024R7X0 Q9Y6D6
PDB IDs		5C5S 5HPY	3LTL 5EE5 5J5C
Enriched GO Terms of Interacting Partners?
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